Aims To investigate the association between corneal hysteresis and the presence of glaucoma and its subtypes in a general Japanese population. Methods We analysed the data of 2338 Japanese community-dwellers aged ≥40 years (1059 men, 1279 women) who underwent an eye examination in 2018 as part of the population-based, cross-sectional Hisayama Study. Participants were divided into quartile levels of corneal hysteresis, which had been measured with an ocular response analyzer. Glaucoma was defined based on the International Society of Geographical and Epidemiological Ophthalmology criteria. We conducted a logistic regression analysis to determine the ORs and their 95% CIs for the presence of outcomes according to the corneal hysteresis quartiles. Results Glaucoma was diagnosed in 154 participants: primary open-angle glaucoma (POAG), n=115; primary angle-closure glaucoma, n=17; exfoliation glaucoma, n=21 and secondary glaucoma without exfoliation glaucoma, n=1. After adjustment for confounders, the OR for prevalent glaucoma was significantly increased in the participants in the first corneal-hysteresis quartile compared with those in the fourth quartile (OR: 1.80; 95% CI: 1.03 to 3.17). Regarding glaucoma subtypes, the first-quartile participants had significantly greater likelihoods of the presence of POAG (OR: 1.63; 95% CI: 1.02 to 2.61) and exfoliation glaucoma (OR: 6.49; 95% CI: 1.44 to 29.30) compared with those in the third and fourth quartiles after adjustment for potential confounders. Conclusions These results demonstrated a significant inverse association between corneal hysteresis and the likelihood of glaucoma, suggesting that the measurement of corneal hysteresis would provide useful information for elucidating the aetiology of glaucoma. All data relevant to the study are included in the article or uploaded as supplementary information.

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日本人群角膜迟滞与青光眼之间的关联：久山研究


目的 研究一般日本人群中角膜迟滞与青光眼及其亚型之间的关联。方法 作为基于人群的横断面久山研究的一部分，我们分析了 2018 年接受眼科检查的 2338 名 40 岁以上日本社区居民（1059 名男性，1279 名女性）的数据。参与者被分为角膜滞后的四分位水平，这是用眼反应分析仪测量的。青光眼是根据国际地理和流行病学眼科学会标准定义的。我们进行了逻辑回归分析，根据角膜滞后四分位数确定结果存在的 OR 及其 95% CI。结果 154 名参与者被诊断为青光眼：原发性开角型青光眼 (POAG)，n=115；原发性闭角型青光眼，n=17；剥脱性青光眼，n=21 和无剥脱性青光眼的继发性青光眼，n=1。调整混杂因素后，与第四个四分位数的参与者相比，第一个角膜滞后四分位数的参与者中青光眼患病率显着增加（OR：1.80；95％CI：1.03至3.17）。关于青光眼亚型，与其他参与者相比，第一四分位数的参与者存在 POAG（OR：1.63；95% CI：1.02 至 2.61）和剥脱性青光眼（OR：6.49；95% CI：1.44 至 29.30）的可能性显着更大在对潜在混杂因素进行调整后，在第三和第四四分位数中。结论 这些结果表明角膜滞后与青光眼的可能性之间存在显着的负相关，这表明角膜滞后的测量将为阐明青光眼的病因提供有用的信息。 与研究相关的所有数据都包含在文章中或作为补充信息上传。