2-Azabicyclo[3.2.1]octanes are nitrogen containing heterocycles with significant potential in the field of drug discovery. This core has been applied as key synthetic intermediate in several total synthesis, while their unique structure can make them a challenging scaffold to acquire. This Minireview summarizes the synthetic approaches to access this bicyclic architecture and highlights its presence in the total synthesis of several target molecules.

中文翻译：

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2-氮杂双环[3.2.1]辛烷支架：合成与应用


2-氮杂双环[3.2.1]辛烷是含氮杂环化合物，在药物发现领域具有巨大潜力。该核心已被用作多种全合成中的关键合成中间体，而其独特的结构使其成为一种具有挑战性的支架。这篇小综述总结了获得这种双环结构的合成方法，并强调了它在几个目标分子的全合成中的存在。