2-Oxabicyclo[2.1.1]hexanes: Synthesis, Properties, and Validation as Bioisosteres of ortho- and meta-Benzenes,Angewandte Chemie International Edition

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2-Oxabicyclo[2.1.1]hexanes: Synthesis, Properties, and Validation as Bioisosteres of ortho- and meta-Benzenes
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2024-03-11 , DOI: 10.1002/anie.202319831
Vadym V Levterov ₁ , Yaroslav Panasiuk ₁ , Oleh Shablykin _{1,

2} , Oleksandr Stashkevych _{1,

3} , Kateryna Sahun ₁ , Artur Rassokhin ₁ , Iryna Sadkova ₁ , Dmytro Lesyk ₄ , Anna Anisiforova ₄ , Yuliia Holota ₄ , Petro Borysko ₄ , Iryna Bodenchuk ₄ , Nataliya M Voloshchuk ₅ , Pavel K Mykhailiuk ₁

Affiliation

A general and practical approach towards substituted 2-oxabicyclo[2.1.1]hexanes has been developed. The obtained compounds have been incorporated into the structure of five drugs and three agrochemicals, and have been validated biologically as bioisosteres of ortho- and meta-benzenes.

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