<br>通过成骨-血管生成耦合和炎症逆转增强血管化骨再生的离子工程微冷冻凝胶,Advanced Functional Materials

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通过成骨-血管生成耦合和炎症逆转增强血管化骨再生的离子工程微冷冻凝胶
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2024-03-10 , DOI: 10.1002/adfm.202400745
Yue Wang ₁ , Xinyu Wang ₁ , Yanyun Pang ₂ , Xiaomin Li ₃ , Chenyuan Gao ₁ , Daixing Zhang ₁ , Guangyu Li ₁ , Yingjie Yu ₁ , Xiaoping Yang ₁ , Qing Cai ₁

Affiliation

天然骨本质上需要平衡的离子微环境来维持骨稳态。因此，设计用于将治疗离子持续释放到骨缺损中的支架对于骨再生具有广阔的前景。镁（Mg）和硅（Si）是必需元素，在骨再生过程中发挥着至关重要的作用，影响免疫调节、血管生成和成骨。在此，开发了多孔冷冻凝胶型有机-无机复合微球作为可注射微支架（表示为GMN）。 GMN能够以优化的比例持续释放Mg/Si离子，对血管化骨再生实现最显着的协同效应。获得各种条件培养基来探索血管生成-成骨耦合，以及骨髓间充质基质细胞（BMSC）和巨噬细胞之间的串扰。同时，自分泌和旁分泌作用在Mg/Si离子和细胞分泌的生物因子的引导下，同时发挥协同调节作用，决定细胞的命运。总的来说，镁/硅离子工程微支架创造了一个有利的微环境，可以有效地增强体内血管化骨组织的再生，为组织工程提供了一个多功能平台。

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Ion-Engineered Microcryogels via Osteogenesis-Angiogenesis Coupling and Inflammation Reversing Augment Vascularized Bone Regeneration

Native bone inherently requires a balanced ionic microenvironment to maintain bone homeostasis. Hence, scaffolds designed for the sustained release of therapeutic ions into bone defects hold great promise for bone regeneration. Magnesium (Mg) and silicon (Si) are essential elements, which play crucial roles in the process of bone regeneration, impacting immunomodulation, angiogenesis, and osteogenesis. Herein, porous cryogel-type organic–inorganic composite microspheres are developed as injectable microscaffolds (denoted as GMN). GMN enables sustained release of Mg/Si ions at an optimized ratio, achieving the most significant synergistic effect on vascularized bone regeneration. Various conditioned media are obtained to explore angiogenesis-osteogenesis coupling, as well as the crosstalk between bone marrow mesenchymal stromal cells (BMSCs) and macrophages. Meanwhile, autocrine and paracrine effects simultaneously play synergistic modulating functions in determining cell fates under the guidance of Mg/Si ions and biofactors secreted by cells. Overall, the Mg/Si ion-engineering microscaffolds create a conducive microenvironment to efficiently augment the regeneration of vascularized bone tissue in vivo, offering a versatile platform for tissue engineering.

更新日期：2024-03-10

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