Changes in populations of regulatory T (T_reg) cells in visceral adipose tissue (VAT) have been linked to metabolic disorders; Valle Torres, Man et al. now characterize T_reg cell heterogeneity in VAT.

In addition to the previously reported population of VAT T_reg cells that express PPARγ and ST2 (also known as IL-33R or IL-1RL1), the authors describe a second VAT T_reg cell subset with high expression of CXCR3 and other T helper 1 (T_H1) cell-associated genes. The ST2⁺ T_reg cell subset was predominant in the VAT of male mice and expanded proportionally to body mass or age, whereas the CXCR3⁺ T_reg cell subset was more prominent in the VAT of female mice, and inversely correlated with body mass.

内脏脂肪组织 (VAT) 中调节性 T (T _reg ) 细胞群的变化与代谢紊乱有关；瓦莱·托雷斯，曼等人。现在描述VAT 中T _{reg细胞异质性的特征。}

除了之前报道的表达 PPARγ 和 ST2（也称为 IL-33R 或 IL-1RL1）的 VAT T _reg细胞群外，作者描述了第二种高表达 CXCR3 和其他 T 辅助细胞 1 的VAT T _reg细胞亚群(TH ₁ ) 细胞相关基因。ST2 ⁺ T _reg细胞亚群在雄性小鼠的 VAT 中占主导地位，并与体重或年龄成比例地扩展，而 CXCR3 ⁺ T _reg细胞亚群在雌性小鼠的 VAT 中更为突出，并且与体重呈负相关。