Photochemistry in Medicinal Chemistry and Chemical Biology,Journal of Medicinal Chemistry

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Photochemistry in Medicinal Chemistry and Chemical Biology
Journal of Medicinal Chemistry ( IF 6.8 ) Pub Date : 2024-03-08 , DOI: 10.1021/acs.jmedchem.3c02109
W Felix Zhu ₁ , Claire Empel ₂ , Sveva Pelliccia ₃ , Rene M Koenigs ₂ , Ewgenij Proschak _{1,

4} , Victor Hernandez-Olmos ₄

Affiliation

Photochemistry has emerged as a transformative force in organic chemistry, significantly expanding the chemical space accessible for medicinal chemistry. Light-induced reactions enable the efficient synthesis of intricate organic structures and have found applications throughout the different stages of the drug discovery and development processes. Moreover, photochemical techniques provide innovative solutions in chemical biology, allowing precise spatiotemporal drug activation and targeted delivery. In this Perspective, we highlight the already numerous remarkable applications and the even more promising future of photochemistry in medicinal chemistry and chemical biology.

中文翻译：

药物化学和化学生物学中的光化学

光化学已成为有机化学领域的一股变革力量，显著扩展了药物化学的化学空间。光诱导反应能够高效合成复杂的有机结构，并已在药物发现和开发过程的不同阶段得到应用。此外，光化学技术为化学生物学提供了创新的解决方案，允许精确的时空药物激活和靶向递送。在这个观点中，我们强调了光化学在药物化学和化学生物学中已经存在的众多显着应用和更有希望的未来。

更新日期：2024-03-08

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