Coordination cages sustained by metal–ligand interactions feature polyhedral architectures and well-defined hollow structures, which have attracted significant attention in recent years due to a variety of structure-guided promising applications. Sulfonylcalix[4]arenes-based coordination cages, termed metal–organic supercontainers (MOSCs), that possess unique multi-pore architectures containing an endo cavity and multiple exo cavities, are emerging as a new family of coordination cages. The well-defined built-in multiple binding domains of MOSCs allow the efficient encapsulation of guest molecules, especially for drug delivery. Here, we critically discuss the design strategy, and, most importantly, the recent advances in research surrounding cavity-specified host–guest chemistry and biomedical applications of MOSCs.

中文翻译：

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磺酰杯[4]芳烃基金属有机超级容器的生物医学应用

由金属-配体相互作用维持的配位笼具有多面体结构和明确的中空结构，近年来由于各种结构引导的有前景的应用而引起了人们的广泛关注。基于磺酰杯[4]芳烃的配位笼，称为金属有机超级容器（MOSC），具有独特的多孔结构，包含一个内腔和多个外腔，正在成为一个新的配位笼家族。MOSC 明确的内置多个结合域允许有效封装客体分子，特别是对于药物输送。在这里，我们批判性地讨论了设计策略，最重要的是，围绕 MOSC 的腔特定主客体化学和生物医学应用的研究的最新进展。