Small molecule adjuvants have the potential to expand the spectrum of gram-positive selective antibiotics to encompass gram-negative bacteria. We identifiy a series of 2-aminobenzimidazole (2-ABI) macrolide adjuvants with activity against Acinetobacter baumannii and Klebsiella pneumoniae. Preliminary mechanism of action studies suggests that adjuvants bind to lipopolysaccharide in K. pneumoniae, and modulate lipooligosaccharide biosynthesis, assembly, or transport in A. baumannii.

中文翻译：

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增强革兰氏阳性选择性抗生素对抗革兰氏阴性细菌的 2-氨基苯并咪唑支架的鉴定

小分子佐剂有可能扩大革兰氏阳性选择性抗生素的范围以涵盖革兰氏阴性细菌。我们鉴定出一系列具有抗鲍曼不动杆菌和肺炎克雷伯菌活性的 2-氨基苯并咪唑 (2-ABI) 大环内酯佐剂。初步作用机制研究表明，佐剂与肺炎克雷伯菌中的脂多糖结合，并调节鲍曼不动杆菌中脂寡糖的生物合成、组装或转运。