Structural basis for different ω-agatoxin IVA sensitivities of the P-type and Q-type Cav2.1 channels,Cell Research

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Structural basis for different ω-agatoxin IVA sensitivities of the P-type and Q-type Cav2.1 channels
Cell Research ( IF 28.1 ) Pub Date : 2024-03-05 , DOI: 10.1038/s41422-024-00940-5
Zhangqiang Li ₁ , Ye Cong ₁ , Tong Wu ₁ , Tongtong Wang ₁ , Xinyao Lou ₁ , Xinyu Yang ₁ , Nieng Yan _{1,

2}

Affiliation

Dear Editor,

Voltage-gated calcium (Ca_v) channels are essential for mediating Ca²⁺ influx in response to membrane depolarization. Activation of Ca_v channels triggers fundamental physiological processes such as muscle contraction, neurotransmitter release, hormone secretion, and synaptic integration.^1,2 The P/Q-type Ca_v channels Ca_v2.1, encoded by CACNA1A and prevalently found in neurons and neuroendocrine cells, play a vital role in the release of neurotransmitters and the regulation of synaptic plasticity and neuronal excitability.³ Ca_v2.1 presents a potential therapeutic target for treating neurological disorders, such as epilepsy and migraine.⁴

中文翻译：

P 型和 Q 型 Cav2.1 通道不同 ω-琼脂毒素 IVA 敏感性的结构基础

尊敬的编辑：

电压门控钙（Ca_v）通道对于响应膜去极化介导 Ca²⁺ 内流至关重要。Ca_v 通道的激活触发基本的生理过程，例如肌肉收缩、神经递质释放、激素分泌和突触整合。^1,2 P/Q 型 Ca_v 通道 Ca_v2.1 由 CACNA1A 编码，普遍存在于神经元和神经内分泌细胞中，在神经递质的释放以及突触可塑性和神经元兴奋性的调节中起着至关重要的作用。³ Ca_v2.1 提出了治疗神经系统疾病（如癫痫和偏头痛）的潜在治疗靶点。⁴

更新日期：2024-03-05

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