Dear Editor,

Voltage-gated calcium (Ca_v) channels are essential for mediating Ca²⁺ influx in response to membrane depolarization. Activation of Ca_v channels triggers fundamental physiological processes such as muscle contraction, neurotransmitter release, hormone secretion, and synaptic integration.^1,2 The P/Q-type Ca_v channels Ca_v2.1, encoded by CACNA1A and prevalently found in neurons and neuroendocrine cells, play a vital role in the release of neurotransmitters and the regulation of synaptic plasticity and neuronal excitability.³ Ca_v2.1 presents a potential therapeutic target for treating neurological disorders, such as epilepsy and migraine.⁴

 亲爱的编辑，

电压门控钙 (Ca _v ) 通道对于介导响应膜去极化的 Ca ²⁺内流至关重要。 Ca _v通道的激活会触发基本的生理过程，例如肌肉收缩、神经递质释放、激素分泌和突触整合。 ^1,2 P/Q 型 Ca _v通道 Ca _v 2.1 由CACNA1A编码，普遍存在于神经元和神经内分泌细胞中，在神经递质的释放以及突触可塑性和神经元兴奋性的调节中发挥着至关重要的作用。 ³ Ca _v 2.1 提出了治疗癫痫和偏头痛等神经系统疾病的潜在治疗靶点。 ⁴