<br>正义与反义：FAM83A 和 FAM83A-AS1 在 Wnt 、 EGFR 、 PI3K、EMT 通路和肿瘤进展中的作用,Biomedicine & Pharmacotherapy

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正义与反义：FAM83A 和 FAM83A-AS1 在 Wnt 、 EGFR 、 PI3K、EMT 通路和肿瘤进展中的作用
Biomedicine & Pharmacotherapy ( IF 6.9 ) Pub Date : 2024-03-02 , DOI: 10.1016/j.biopha.2024.116372
Chenshu Zhao ₁ , Xiaowen Li ₁ , Rui Zhang ₁ , Hao Lyu ₁ , Shuai Xiao ₁ , Dong Guo ₁ , Declan William Ali ₂ , Marek Michalak ₃ , Xing-Zhen Chen ₄ , Cefan Zhou ₁ , Jingfeng Tang ₁

Affiliation

越来越多的研究表明，FAM83A 是序列相似性 83 家族（FAM83）的成员，由 8 个成员组成，是参与多个信号通路的关键肿瘤治疗靶点。据报道，FAM83A 在胰腺癌、肺癌、乳腺癌和其他恶性肿瘤模型中调节 Wnt/β-catenin、EGFR、MAPK、EMT 等信号通路和生理过程中起重要作用。此外，FAM83A 的表达可能受到恶性肿瘤中失调的多种非编码 RNA 的显着影响，其失调对于恶性过程至关重要。在这些非编码 RNA 中，最值得注意的是 FAM83A 本身的反义长链非编码（Lnc） RNA （FAM83A-AS1），表明 FAM83A 和 FAM83A-AS1 之间具有突出的协同致癌作用。在本研究中，详细综述了 FAM83A 和 FAM83A-AS1 在 Wnt/β-catenin 和 EGFR 信号通路中协同发挥作用的具体机制，这将指导后续研究。我们还描述了 FAM83A 和 FAM83A-AS1 在肿瘤治疗中的应用，并为后续药物靶点开发和联合治疗策略提供了一定的理论依据。

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Sense and anti-sense: Role of FAM83A and FAM83A-AS1 in Wnt, EGFR, PI3K, EMT pathways and tumor progression

An increasing number of studies have shown that FAM83A, a member of the family with sequence similarity 83 (FAM83), which consists of eight members, is a key tumor therapeutic target involved in multiple signaling pathways. It has been reported that FAM83A plays essential roles in the regulation of Wnt/β-catenin, EGFR, MAPK, EMT, and other signaling pathways and physiological processes in models of pancreatic cancer, lung cancer, breast cancer, and other malignant tumors. Moreover, the expression of FAM83A could be significantly affected by multiple noncoding RNAs that are dysregulated in malignant tumors, the dysregulation of which is essential for the malignant process. Among these noncoding RNAs, the most noteworthy is the antisense long noncoding (Lnc) RNA of FAM83A itself (FAM83A-AS1), indicating an outstanding synergistic carcinogenic effect between FAM83A and FAM83A-AS1. In the present study, the specific mechanisms by which FAM83A and FAM83A-AS1 cofunction in the Wnt/β-catenin and EGFR signaling pathways were reviewed in detail, which will guide subsequent research. We also described the applications of FAM83A and FAM83A-AS1 in tumor therapy and provided a certain theoretical basis for subsequent drug target development and combination therapy strategies.

更新日期：2024-03-02

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