Neurodevelopmental toxicity and molecular mechanism of environmental concentration of tetrabromobisphenol A bis (2- hydroxyethyl) ether exposure to sexually developing male SD rats,Chemosphere

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Neurodevelopmental toxicity and molecular mechanism of environmental concentration of tetrabromobisphenol A bis (2- hydroxyethyl) ether exposure to sexually developing male SD rats
Chemosphere ( IF 8.1 ) Pub Date : 2024-03-03 , DOI: 10.1016/j.chemosphere.2024.141378
Mengna Luo ₁ , Chang Song ₁ , Jiali Zuo ₁ , Weiwei Feng ₁ , Chaoqiong Wu ₁ , Xin Geng ₁ , Emmanuel Sunday Okeke ₂ , Guanghua Mao ₁ , Yao Chen ₁ , Ting Zhao ₃ , Xiangyang Wu ₁

Affiliation

Tetrabromobisphenol A bis (2- hydroxyethyl) ether (TBBPA-DHEE), as one of the main derivatives of Tetrabromobisphenol A, been attracted attention for its health risks. In this study, the neurotoxicity, mechanism, and susceptivity of TBBPA-DHEE exposure to sexually developing male rats were systematically studied. Neurobehavioral research showed that TBBPA-DHEE exposure could significantly affect the behavior, learning,and memory abilities of male-developing rats, and aggravate their depression. TBBPA-DHEE exposure could inhibit the secretion of neurotransmitters. Transcriptomics studies show that TBBPA-DHEE can significantly affect gene expression, and a total of 334 differentially expressed genes are enriched. GO function enrichment analysis shows that TBBPA-DHEE exposure can significantly affect the expression of genes related to synapses and cell components. KEGG function enrichment analysis shows that TBBPA-DHEE exposure can significantly affect the expression of signal pathways related to nerves, nerve development, and signal transduction. Susceptibility analysis showed that female rats were more susceptible to TBBPA-DHEE exposure than male rats. Therefore, TBBPA-DHEE exposure has neurodevelopmental toxicity to male developmental rats, and female developmental rats are more susceptible than male developmental rats. Its possible molecular mechanism is that TBBPA-DHEE may inhibit the secretion of neurotransmitters and affect signal pathways related to neurodevelopment and signal transduction.

中文翻译：

环境浓度四溴双酚A双(2-羟乙基)醚暴露对性发育雄性SD大鼠的神经发育毒性及分子机制

四溴双酚A双(2-羟乙基)醚(TBBPA-DHEE)作为四溴双酚A的主要衍生物之一，因其健康风险而受到关注。本研究系统地研究了 TBBPA-DHEE 暴露对性发育雄性大鼠的神经毒性、机制和敏感性。神经行为研究表明，TBBPA-DHEE暴露会显着影响雄性发育大鼠的行为、学习和记忆能力，并加剧其抑郁症。 TBBPA-DHEE暴露可抑制神经递质的分泌。转录组学研究表明TBBPA-DHEE能够显着影响基因表达，总共富集了334个差异表达基因。 GO功能富集分析表明，TBBPA-DHEE暴露可显着影响突触和细胞成分相关基因的表达。 KEGG功能富集分析表明TBBPA-DHEE暴露可显着影响神经相关信号通路的表达、神经发育和信号转导。敏感性分析显示雌性大鼠比雄性大鼠更容易受到TBBPA-DHEE暴露的影响。因此，TBBPA-DHEE暴露对雄性发育大鼠具有神经发育毒性，雌性发育大鼠比雄性发育大鼠更敏感。其可能的分子机制是TBBPA-DHEE可能抑制神经递质的分泌，影响神经发育和信号转导相关的信号通路。

更新日期：2024-03-03

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