<br>离子液体作为增强透皮给药的有效技术：设计原理、作用、机制和未来挑战,Asian Journal of Pharmaceutical Sciences

当前位置： X-MOL 学术 › Asian J. Pharm. Sci. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

离子液体作为增强透皮给药的有效技术：设计原理、作用、机制和未来挑战
Asian Journal of Pharmaceutical Sciences ( IF 10.7 ) Pub Date : 2024-03-06 , DOI: 10.1016/j.ajps.2024.100900
Xuejun Chen ₁ , Ziqing Li ₁ , Chunrong Yang ₁ , Degong Yang _{1,

2}

Affiliation

离子液体（IL）已被证明是增强药物透皮吸收的有效技术。然而，由于ILs独特的结构成分，有效ILs的设计和作用机制的阐明仍有待探索。在这篇综述中，讨论了透皮给药系统（TDDS）理想离子液体的基本设计原则，考虑到熔点、皮肤渗透性和毒性，这些取决于离子的摩尔比、类型、官能团和离子间相互作用。其次，描述了IL通过不同作用对TDDS发展的贡献：作为新型皮肤渗透促进剂，增强药物的透皮吸收；作为提高药物在载体中溶解度的新型溶剂；作为新型活性药物成分（API-IL），用于调节药物的皮肤渗透性、溶解度、释放和药代动力学行为；以及作为用于开发智能医疗材料的新型聚合物。此外，还总结了多种作用机制，主要包括IL、药物、聚合物和皮肤成分之间的相互作用。最后，讨论了与离子液体相关的未来挑战，包括潜在的定量结构-活性关系、阴离子、药物、聚合物和皮肤微环境之间复杂的相互作用力、长期稳定性和安全性问题。综上所述，本文将推动基于IL的TDDS的发展。

"点击查看英文标题和摘要"

Ionic liquids as the effective technology for enhancing transdermal drug delivery: Design principles, roles, mechanisms, and future challenges

Ionic liquids (ILs) have been proven to be an effective technology for enhancing drug transdermal absorption. However, due to the unique structural components of ILs, the design of efficient ILs and elucidation of action mechanisms remain to be explored. In this review, basic design principles of ideal ILs for transdermal drug delivery system (TDDS) are discussed considering melting point, skin permeability, and toxicity, which depend on the molar ratios, types, functional groups of ions and inter-ionic interactions. Secondly, the contributions of ILs to the development of TDDS through different roles are described: as novel skin penetration enhancers for enhancing transdermal absorption of drugs; as novel solvents for improving the solubility of drugs in carriers; as novel active pharmaceutical ingredients (API-ILs) for regulating skin permeability, solubility, release, and pharmacokinetic behaviors of drugs; and as novel polymers for the development of smart medical materials. Moreover, diverse action mechanisms, mainly including the interactions among ILs, drugs, polymers, and skin components, are summarized. Finally, future challenges related to ILs are discussed, including underlying quantitative structure-activity relationships, complex interaction forces between anions, drugs, polymers and skin microenvironment, long-term stability, and safety issues. In summary, this article will promote the development of TDDS based on ILs.

更新日期：2024-03-06

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文

全部期刊列表>>