Background The aims of this narrative review are to examine the impact of proctocolectomy on the liver in patients with primary sclerosing cholangitis and ulcerative colitis (PSC-UC), mainly focusing on graft loss, and to compare the different proctocolectomy techniques to help determine which is the best for PSC-UC patients. Methods A literature search was performed using the online databases MEDLINE and Embase. Studies found via the search were evaluated against both inclusion and exclusion criteria by two independent reviewers (TR and JS). Relevant studies were included in the review. Results Seven studies were deemed relevant through the literature search and review process and another one was included via other sources, therefore, eight studies were included in the final review. Conclusions Proctocolectomy does not appear to have a negative impact on the liver and ileostomy appears to have better outcomes in terms of graft loss compared with ileal pouch-anal anastomosis. However, more high-quality studies on this topic are required as the existing literature is limited, and therefore, the findings should not be overinterpreted. Data is available upon request.

中文翻译：

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原发性硬化性胆管炎和溃疡性结肠炎患者直肠结肠切除术后的肝脏结局


背景 本叙述性综述的目的是检查直肠结肠切除术对原发性硬化性胆管炎和溃疡性结肠炎 (PSC-UC) 患者肝脏的影响，主要关注移植物丢失，并比较不同的直肠结肠切除术技术，以帮助确定哪种技术更适合最适合 PSC-UC 患者。方法 使用在线数据库 MEDLINE 和 Embase 进行文献检索。两名独立评审员（TR 和 JS）根据纳入和排除标准对通过检索发现的研究进行了评估。相关研究已纳入综述。结果 通过文献检索和综述过程，有 7 项研究被认为是相关的，另一项研究是通过其他来源纳入的，因此，最终综述中纳入了 8 项研究。结论 直肠结肠切除术似乎不会对肝脏产生负面影响，并且与回肠贮袋肛管吻合术相比，回肠造口术在移植物丢失方面似乎具有更好的结果。然而，由于现有文献有限，因此需要对该主题进行更多高质量的研究，因此不应过度解释研究结果。数据可根据要求提供。