Relationship between hemoglobin and grip strength in older adults: the ActiFE study,Aging Clinical and Experimental Research

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Relationship between hemoglobin and grip strength in older adults: the ActiFE study
Aging Clinical and Experimental Research ( IF 3.4 ) Pub Date : 2024-03-07 , DOI: 10.1007/s40520-024-02698-7
Theresa Hammer _{1,

2} , Ulrike Braisch _{1,

3} , Dietrich Rothenbacher ₃ , Michael Denkinger _{1,

2,

4} , Dhayana Dallmeier _{1,

4,

5}

Affiliation

Introduction

Although anemia is associated with low muscle strength, hemoglobin has been rarely studied considering ferritin.

Aim

To analyze the association between hemoglobin and grip strength in community-dwelling older adults.

Methods

We used data from a German cohort of adults ≥ 65 years, excluding those with CRP > 10 mg/L or taking iron supplements. Grip strength (kg) was measured using a Jamar dynamometer. Analysis was performed using multiple linear regression, adjusted for established confounders. Due to interaction, age-stratified (< 80, 80 +), further sex-stratified analysis in those < 80 years old and ferritin-stratified in men < 80 years were performed.

Results

In total, 1294 participants were included in this analysis (mean age 75.5 years, 549 (42.3%) women, 910 (70.3%) < 80 years). On average, hemoglobin and grip strength were 14.9 g/dL and 41.3 kg for men, 13.9 g/dL and 25.1 kg for women. Hemoglobin was significantly positively associated with grip strength only among women < 80 years (β 0.923 [95% CI 0.196, 1.650]). For men < 80 years, the association was significant when ferritin was ≥ 300 µg/L (β 2.028 [95% CI 0.910, 3.146]). No association was detected among those participants 80 + .

Discussion and conclusions

Our data show an association between hemoglobin and grip strength only in women < 80 years old. For men < 80 years, the association was only significant with ferritin levels ≥ 300 µg/L. Considering the decreasing levels of hemoglobin and grip strength and the high prevalence of iron deficiency in older adults further analyses investigating this relationship with more iron specific parameters such as transferrin saturation are warranted.

中文翻译：

老年人血红蛋白与握力之间的关系：ActiFE 研究

介绍

尽管贫血与肌肉力量低下有关，但很少研究血红蛋白考虑铁蛋白。

目的

分析社区老年人血红蛋白与握力之间的关联。

方法

我们使用了 65 岁以上德国成年人队列的数据，不包括 CRP > 10 mg/L 或服用铁补充剂的人群。使用贾马尔测力计测量握力（kg）。使用多元线性回归进行分析，并针对已确定的混杂因素进行调整。由于相互作用，对年龄分层（< 80、80 +）、< 80 岁的人群进行了进一步的性别分层分析，并对 < 80 岁的男性进行了铁蛋白分层。

结果

此次分析总共包括 1294 名参与者（平均年龄 75.5 岁，其中 549 名 (42.3%) 女性，910 名 (70.3%) < 80 岁）。平均而言，男性血红蛋白和握力分别为 14.9 克/分升和 41.3 公斤，女性分别为 13.9 克/分升和 25.1 公斤。仅在 <80 岁的女性中，血红蛋白与握力呈显着正相关（β 0.923 [95% CI 0.196, 1.650]）。对于 < 80 岁的男性，当铁蛋白≥ 300 µg/L 时，相关性显着 (β 2.028 [95% CI 0.910, 3.146])。在 80 岁以上的参与者中没有发现任何关联。