The goal of this work was to develop a reliable method to produce the well-validated microglial activation PET tracer, [F]DPA-714, routinely for clinical and preclinical research using an IBA Synthera®. Optimization of literature methods included reduced precursor mass and use of TBA HCO as the phase transfer agent in place of Kryptofix® 222 in a 65-min synthesis with an average activity yield of 24.6 ± 3.8% (n = 5). Successful quality control testing and process validation results are reported.

中文翻译：

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在市售 IBA Synthera® 上自动放射合成 [18F]DPA-714


这项工作的目标是开发一种可靠的方法来生产经过充分验证的小胶质细胞激活 PET 示踪剂 [F]DPA-714，通常使用 IBA Synthera® 进行临床和临床前研究。文献方法的优化包括减少前体质量并使用 TBA HCO 作为相转移剂代替 Kryptofix® 222，合成时间为 65 分钟，平均活性产率为 24.6 ± 3.8% (n = 5)。报告成功的质量控制测试和工艺验证结果。