Most studies on the relationship between childhood adversity and negative outcomes across the lifespan have focused on individual exposures or outcomes—an approach that has been limited in its ability to elucidate mechanisms or causality. We propose a new framework for examining the relationship between childhood adversity and negative outcomes—the bio-exposome. In this model, we aim to understand the interconnections between every aspect of biology and the exposome, and the way disparate biological and exposome factors shape, and are shaped by, one another. Once we understand when, in which contexts and towards whom stress calibration interventions should be targeted, through examination of the bio-exposome, we could facilitate prevention of some of the major causes of morbidity across the lifespan. To examine the bio-exposome, we offer a new research agenda that embraces complexity science, large datasets and collaboration across a wide range of scientific disciplines.

大多数关于童年逆境与一生中负面结果之间关系的研究都集中在个人暴露或结果上——这种方法在阐明机制或因果关系的能力方面受到限制。我们提出了一个新的框架来检查童年逆境和负面结果之间的关系——生物暴露组。在这个模型中，我们的目标是了解生物学和暴露组的各个方面之间的相互联系，以及不同的生物学和暴露组因素如何相互影响和相互影响。一旦我们了解压力校准干预措施应在何时、在何种情况下以及针对谁，通过检查生物暴露组，我们就可以促进预防整个生命周期中发病的一些主要原因。为了检查生物暴露，我们提供了一个新的研究议程，其中包括复杂性科学、大型数据集和跨广泛科学学科的协作。