The efficient management of skin wounds for rapid and scarless healing represents a major clinical unmet need. Nonhealing skin wounds and undesired scar formation impair quality of life and result in high healthcare expenditure worldwide. The skin-colonizing microbiota contributes to maintaining an intact skin barrier in homeostasis, but it also participates in the pathogenesis of many skin disorders, including aberrant wound healing, in many respects. This review focuses on the composition of the skin microbiome in cutaneous wounds of different types (i.e. acute and chronic) and with different outcomes (i.e. nonhealing and hypertrophic scarring), mainly based on next-generation sequencing analyses; furthermore, we discuss the mechanistic insights into host–microbe and microbe–microbe interactions during wound healing. Finally, we highlight potential therapeutic strategies that target the skin microbiome to improve healing outcomes.

中文翻译：

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皮肤微生物组在伤口愈合中的作用


有效管理皮肤伤口以实现快速、无疤痕愈合是临床上未满足的主要需求。无法愈合的皮肤伤口和不良疤痕的形成会损害生活质量，并导致全球医疗保健支出高昂。皮肤定殖微生物群有助于维持完整的皮肤屏障稳态，但它也在许多方面参与许多皮肤疾病的发病机制，包括异常伤口愈合。本综述主要基于下一代测序分析，重点关注不同类型（即急性和慢性）和不同结果（即不愈合和增生性疤痕）的皮肤伤口中皮肤微生物组的组成；此外，我们还讨论了伤口愈合过程中宿主-微生物和微生物-微生物相互作用的机制见解。最后，我们强调了针对皮肤微生物组以改善愈合结果的潜在治疗策略。