MRE11 mobilizes CGAS and drives ZBP1-dependent necroptosis,Cell Research

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MRE11 mobilizes CGAS and drives ZBP1-dependent necroptosis
Cell Research ( IF 28.1 ) Pub Date : 2024-03-05 , DOI: 10.1038/s41422-024-00939-y
Manuel Beltrán-Visiedo ₁ , Siddharth Balachandran ₂ , Lorenzo Galluzzi _{1,

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Affiliation

Recent data from Cho et al. demonstrate that the DNA repair protein MRE11 liberates CGAS from nucleosomes to license type I interferon secretion upon oncogenic stress and ionizing radiation. MRE11-mediated CGAS activation culminates in ZBP1-driven necroptosis, which is essential for limiting mammary oncogenesis.

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