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VMAT structures reveal exciting targets for drug development
Trends in Pharmacological Sciences ( IF 13.9 ) Pub Date : 2024-02-29 , DOI: 10.1016/j.tips.2024.02.004
Shimon Schuldiner , Lucy R. Forrest

Vesicular monoamine transporter (VMAT)-2 has a crucial role in the neurotransmission of biogenic amines. Recently, , , , and individually reported cryo-electron microscopy (EM) structures of human VMAT2, offering opportunities for developing improved therapeutics and deep insights into the functioning of this protein.

中文翻译:

VMAT 结构揭示了令人兴奋的药物开发目标

囊泡单胺转运蛋白 (VMAT)-2 在生物胺的神经传递中发挥着至关重要的作用。最近, 、 、 和单独报道了人类 VMAT2 的冷冻电子显微镜 (EM) 结构,为开发改进的治疗方法和深入了解该蛋白质的功能提供了机会。
更新日期:2024-02-29
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