In a bioeconomy that relies on synthetic DNA sequences, the ability to ensure their authenticity is critical. DNA watermarks can encode identifying data in short sequences and can be combined with error correction and encryption protocols to ensure that sequences are robust to errors and securely communicated. New digital signature techniques allow for public verification that a sequence has not been modified and can contain sufficient information for synthetic DNA to be self-documenting. In translating these techniques from bacteria to more complex genetically modified organisms (GMOs), special considerations must be made to allow for public verification of these products. We argue that these approaches should be widely implemented to assert authorship, increase the traceability, and detect the unauthorized use of synthetic DNA.

中文翻译：

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验证合成 DNA 序列的加密方法


在依赖合成 DNA 序列的生物经济中，确保其真实性的能力至关重要。 DNA 水印可以对短序列中的识别数据进行编码，并可以与纠错和加密协议相结合，以确保序列对错误具有鲁棒性并安全地进行通信。新的数字签名技术允许公众验证序列没有被修改，并且可以包含合成 DNA 自我记录所需的足够信息。在将这些技术从细菌转化为更复杂的转基因生物 (GMO) 时，必须特别考虑以便对这些产品进行公开验证。我们认为，这些方法应该广泛实施，以维护作者身份、提高可追溯性并检测合成 DNA 的未经授权使用。