<br>基于 Fenton 反应的 pH 响应型载铁碳质纳米粒子用于化学动力学治疗,Journal of Materials Chemistry B

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基于 Fenton 反应的 pH 响应型载铁碳质纳米粒子用于化学动力学治疗
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2024-03-01 , DOI: 10.1039/d3tb02875e
Nianlu Li _{1,

2} , Gaorui Zhang _{3,

4} , Jinhua Zhan ₁ , Dexin Yu _{3,

4}

Affiliation

基于芬顿反应的化学动力学疗法是癌症治疗的一种形式，通过促进铁离子的催化反应可以显着提高其疗效。最佳治疗需要一种具有高催化能力和低生物毒性的系统，能够有效抑制肿瘤进展。在这项研究中，制备了具有芬顿催化活性的载铁碳质纳米粒子（CNPs@Fe）并将其应用于癌症的化学动力学治疗。通过焦糖化反应从葡萄糖衍生的碳质纳米颗粒表现出高生物相容性。此外，碳质纳米粒子中的芳香族结构有助于加速电子转移，从而增强H ₂ O ₂的催化分解，从而形成高反应性的羟基自由基(˙OH)。在pH 6.0（代表肿瘤微环境弱酸性）下，CNPs@Fe分解H ₂ O ₂的Fenton催化活性比Fe ²⁺高15.3倍，比Fe ₃ O ₄高28.3倍通过显色反应。通过使用高分辨率质谱分析碳质纳米粒子的化学成分揭示了增强的原因。所开发的芬顿剂还在体外和体内抗癌研究中表现出显着的治疗效果和最小的副作用。这项工作提出了一种促进活性氧（ROS）产生的新方法，用于癌症的化学动力学治疗。

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pH-responsive iron-loaded carbonaceous nanoparticles for chemodynamic therapy based on the Fenton reaction

The Fenton reaction-based chemodynamic therapy is a form of cancer therapy, and its efficacy can be significantly improved by promoting catalytic reactions involving iron ions. A system with high catalytic capacity and low biological toxicity that effectively inhibits tumor progression is required for optimal treatment. In this study, iron-loaded carbonaceous nanoparticles (CNPs@Fe) with Fenton catalytic activity were fabricated and applied for the chemodynamic therapy of cancer. The carbonaceous nanoparticles derived from glucose via a caramelization reaction demonstrated high biocompatibility. Besides, aromatic structures in the carbonaceous nanoparticles helped accelerate electron transfer to enhance the catalytic decomposition of H₂O₂, resulting in the formation of highly reactive hydroxyl radicals (˙OH). At pH 6.0 (representing weak acidity in the tumor microenvironment), the Fenton catalytic activity of CNPs@Fe in the decomposition of H₂O₂ was 15.3 times higher than that of Fe²⁺ and 28.3 times higher than that of Fe₃O₄ via a chromogenic reaction. The reasons for the enhancement were revealed by analyzing the chemical composition of carbonaceous nanoparticles using high-resolution mass spectra. The developed Fenton agent also demonstrated significant therapeutic effectiveness and minimal side effects in in vitro and in vivo anticancer studies. This work proposes a novel approach to promote the generation of reactive oxygen species (ROS) for the chemodynamic therapy of cancer.

更新日期：2024-03-01

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