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Pre-existing antibody allows for maturation of new B cells in ‘recall’ germinal centres
Nature Reviews Immunology ( IF 67.7 ) Pub Date : 2024-03-01 , DOI: 10.1038/s41577-024-01012-w
Jake Herb , Maria Curotto de Lafaille

Re-exposure to a previously encountered antigen leads to robust antibody responses and the formation of ‘recall’ germinal centres. A preprint by Schiepers et al. shows that antibody feedback in these germinal centres ensures the maturation of naive B cells that can target escape epitopes.

中文翻译:

预先存在的抗体允许“回忆”生发中心中的新 B 细胞成熟

重新暴露于先前遇到的抗原会导致强烈的抗体反应并形成“回忆”生发中心。Schiepers 等人的预印本。研究表明,这些生发中心的抗体反馈确保了能够靶向逃逸表位的初始 B 细胞的成熟。
更新日期:2024-03-01
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