Sodium Sulfobutylether-β-cyclodextrin (SBE-β-CD) is a derivative of β-cyclodextrin, characterized by its stereo structure, which closely resembles a truncated cone with a hydrophobic internal cavity. The solubility of insoluble substances within the hydrophobic cavity is significantly enhanced, reducing contact between the guest and the environment. Consequently, SBE-β-CD is frequently employed as a co-solvent and stabilizer. As the research progresses, it has been observed that the inclusion of SBE-β-CD is reversible and competitive. Besides, some inclusion complexes undergo distinct physicochemical property alterations compared to the guests. Additionally, certain guests exhibit varying inclusions with SBE-β-CD at different concentrations. These features have contributed to the expanding applications. SBE-β-CD finds widespread application in pharmaceutics as a protective agent and pK regulator, in pharmaceutical analysis as a chiral substance separator, and in biomedical engineering for encapsulating dyes and modifying sensors. The article will elaborate in detail on the physicochemical properties of SBE-β-CD, encapsulation principles, and factors influencing the formation of inclusion complexes. Furthermore, the review focuses on the application of SBE-β-CD through encapsulation in pharmaceutics, pharmaceutical analysis, and biomedical engineering. Finally, the prospects and potential applications of SBE-β-CD are discussed.

中文翻译：

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磺丁基醚-β-环糊精钠基于包封的应用


磺丁基醚-β-环糊精钠（SBE-β-CD）是β-环糊精的衍生物，其立体结构非常类似于具有疏水内腔的截锥体。疏水腔内不溶性物质的溶解度显着增强，减少了客体与环境之间的接触。因此，SBE-β-CD 经常被用作共溶剂和稳定剂。随着研究的进展，人们发现SBE-β-CD的包合是可逆的、竞争性的。此外，与客体相比，一些包合物经历了明显的物理化学性质改变。此外，某些客体在不同浓度下表现出不同的 SBE-β-CD 内含物。这些功能有助于扩大应用范围。 SBE-β-CD 在制药业中作为保护剂和 pK 调节剂、在药物分析中作为手性物质分离剂以及在生物医学工程中用于封装染料和修饰传感器得到广泛应用。文章将详细阐述SBE-β-CD的理化性质、包封原理以及影响包合物形成的因素。此外，本综述重点关注 SBE-β-CD 通过封装在药剂学、药物分析和生物医学工程中的应用。最后，讨论了SBE-β-CD的前景和潜在应用。