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I2-DMSO-Mediated Construction of 2,3- and 2,4-Disubstituted Pyrimido[1,2-b]indazole Skeletons
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2024-02-29 , DOI: 10.1021/acs.joc.3c02761 Lin-Lin Ma 1 , You Zhou 2 , Yong-Xing Tang 2 , Ting Chen 2 , Zheng-Hao Wang 2 , Yan-Dong Wu 2 , Jun-Gang Wang 1 , An-Xin Wu 2
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2024-02-29 , DOI: 10.1021/acs.joc.3c02761 Lin-Lin Ma 1 , You Zhou 2 , Yong-Xing Tang 2 , Ting Chen 2 , Zheng-Hao Wang 2 , Yan-Dong Wu 2 , Jun-Gang Wang 1 , An-Xin Wu 2
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An efficient synthetic method for constructing 2,3- and 2,4-disubstituted pyrimidio[1,2-b]indazole skeletons through I2-DMSO-mediated and substrate-controlled regioselective [4 + 2] cyclization is reported. The reaction conditions are mild, its operation is simple, and the substrate scope is wide. More than 60 pyrimidio[1,2-b]indazole derivatives have been synthesized, providing a new methodology for constructing related molecules and potentially enriching bioactive-molecule libraries.
中文翻译：
I2-DMSO 介导的 2,3- 和 2,4-二取代嘧啶并[1,2-b]吲唑骨架的构建
报道了一种通过 I 2 -DMSO 介导和底物控制的区域选择性 [4 + 2] 环化构建 2,3- 和 2,4-二取代嘧啶并[1,2- b ]吲唑骨架的有效合成方法。反应条件温和，操作简单，底物范围广。已合成了60多种嘧啶并[1,2- b ]吲唑衍生物，为构建相关分子和潜在丰富生物活性分子库提供了新的方法。
更新日期：2024-02-29
中文翻译：
I2-DMSO 介导的 2,3- 和 2,4-二取代嘧啶并[1,2-b]吲唑骨架的构建
报道了一种通过 I 2 -DMSO 介导和底物控制的区域选择性 [4 + 2] 环化构建 2,3- 和 2,4-二取代嘧啶并[1,2- b ]吲唑骨架的有效合成方法。反应条件温和，操作简单，底物范围广。已合成了60多种嘧啶并[1,2- b ]吲唑衍生物，为构建相关分子和潜在丰富生物活性分子库提供了新的方法。
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