Background/aims Age-related macular degeneration (AMD) and cancer may share similar risk factors, indicating possible common pathogenic pathways. We aimed to describe the site-specific cancer risk based on the relationship of AMD with visual disability (VD) status. Methods This was a population-based cohort study using data from the Korean National Health Insurance Service database (2009–2019) including patients who participated in a national health screening programme in 2009. The subjects were categorised based on the presence of AMD and VD. The occurrence of cancer was identified using principal diagnosis according to the International Classification of Disease, 10th revision codes in claims data. The Cox regression hazard model was used to compare HRs of site-specific cancer. Results Among 4 088 814 participants, 51 596 had AMD of which 3683 subjects had VD. The mean follow-up period was 9.6 years. The overall cancer risk was generally null, but the risk of hypervascular cancer such as thyroid cancer (adjusted HR (aHR) 1.10, 95% CI 1.00 to 1.20) and renal cancer (aHR 1.16, 95% CI 1.00 to 1.33) was higher and the risk of stomach cancer (aHR 0.89, 95% CI 0.84 to 0.94) was lower in the AMD group than in the non-AMD group. Conclusion This study demonstrated a possible association between AMD and several cancers. Increased renal and thyroid cancer risk among patients with AMD could indicate that AMD is associated with hypervascular cancer. Further studies in which additional databases are used and the underlying detailed mechanisms evaluated are needed to validate our results. Data are available on reasonable request. The data that support the findings of this study are available from the Korean National Health Insurance Service (KNHIS) and were used under licence for the current study (). Restrictions apply to their availability (data are not publicly available). Data are available from the authors with permission of the KNHIS on reasonable request.

中文翻译：

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年龄相关性黄斑变性与癌症风险之间的关联


背景/目标 年龄相关性黄斑变性 (AMD) 和癌症可能具有相似的危险因素，表明可能存在共同的致病途径。我们的目的是根据 AMD 与视力障碍 (VD) 状态的关系来描述特定部位的癌症风险。方法 这是一项基于人群的队列研究，使用韩国国民健康保险服务数据库（2009-2019 年）的数据，包括 2009 年参加国民健康筛查计划的患者。受试者根据 AMD 和 VD 的存在情况进行分类。癌症的发生是根据索赔数据中的国际疾病分类第 10 版修订代码进行主要诊断来确定的。 Cox 回归风险模型用于比较特定部位癌症的 HR。结果 在 4 088 814 名参与者中，51 596 名受试者患有 AMD，其中 3683 名受试者患有 VD。平均随访期为 9.6 年。总体癌症风险通常为零，但甲状腺癌（调整后 HR (aHR) 1.10，95% CI 1.00 至 1.20）和肾癌（aHR 1.16，95% CI 1.00 至 1.33）等富血管癌症的风险较高，并且AMD 组患胃癌的风险（aHR 0.89，95% CI 0.84 至 0.94）低于非 AMD 组。结论 这项研究证明了 AMD 与多种癌症之间可能存在关联。 AMD 患者患肾癌和甲状腺癌的风险增加可能表明 AMD 与富血管癌有关。需要使用额外的数据库并评估潜在的详细机制的进一步研究来验证我们的结果。可根据合理要求提供数据。 支持本研究结果的数据可从韩国国民健康保险公团 (KNHIS) 获得，并在当前研究的许可下使用 ( ）。其可用性受到限制（数据不公开）。经 KNHIS 合理请求许可，作者可提供数据。