Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases,npj Aging

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Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases
npj Aging ( IF 4.1 ) Pub Date : 2024-02-27 , DOI: 10.1038/s41514-024-00143-7
Naomi Shek ₁ , Anna-Maria Choy ₂ , Chim C Lang ₂ , Bruce E Miller ₃ , Ruth Tal-Singer ₄ , Charlotte E Bolton ₅ , Neil C Thomson ₆ , James D Chalmers ₂ , Matt J Bown ₇ , David E Newby ₈ , Faisel Khan ₁ , Jeffrey T J Huang ₁

Affiliation

Aging is a major driving force for many diseases but the relationship between chronological age, the aging process and age-related diseases is not fully understood. Fragmentation and loss of ultra-long-lived elastin are key features in aging and several age-related diseases leading to increased mortality. By comparing the relationship between age and elastin turnover with healthy volunteers, we show that accelerated elastin turnover by age-disease interaction is a common feature of age-related diseases.

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