The literature is filled with citations reporting an increased incidence of chronic dry eye disease, also known as keratoconjunctivitis sicca, in patients with systemic autoimmune diseases such as rheumatoid arthritis, Sjögren's Syndrome, systemic sclerosis and lupus. As the most environmentally exposed mucosal surface of the body, the conjunctiva constantly responds to environmental challenges which are typically self limited, but when persistent and unresolved may provoke pathogenic innate and adaptive immune reactions.

中文翻译：

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系统性自身免疫性疾病中干燥性角结膜炎发展的免疫学基础：先天免疫传感器的作用


文献中充斥着报道称患有系统性自身免疫性疾病（例如类风湿性关节炎、干燥综合征、系统性硬化症和狼疮）的患者慢性干眼病（也称为干燥性角结膜炎）发病率增加的引文。作为身体暴露在环境中最多的粘膜表面，结膜不断地对环境挑战做出反应，这些挑战通常是自我限制的，但当持续且未解决时，可能会引发致病性先天和适应性免疫反应。