<br>揭示HKUST-1的潜力：合成、活化、优势和生物医学应用,Journal of Materials Chemistry B

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揭示HKUST-1的潜力：合成、活化、优势和生物医学应用
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2024-02-27 , DOI: 10.1039/d3tb02929h
Liuxuan Yang _{1,

2} , Ke Wang _{1,

2} , Ling Guo ₃ , Xiao Hu ₂ , Meiling Zhou ₁

Affiliation

金属有机框架（MOF）已成为一类独特的纳米结构材料，由金属离子或簇与有机配体的自组装产生，在药物输送、气体催化和电化学等领域提供了广泛的应用传感。其中，HKUST-1是一种铜基MOF，因其卓越的三维多孔结构而受到广泛关注。 HKUST-1 由铜离子和苯-1,3,5-三甲酸组成，具有非凡的比表面积和显着的孔隙率，使其成为生物医学领域的有前途的候选者。值得注意的是，铜离子的掺入赋予 HKUST-1 显着的活性，包括抗肿瘤、抗菌和促进伤口愈合的特性。在这篇综合综述中，我们深入研究了 HKUST-1 制备中采用的各种合成方法和激活途径。我们还探讨了 HKUST-1 在结构特性和功能方面的独特优势。此外，我们还研究了 HKUST-1 令人兴奋且快速发展的生物医学应用。从其在肿瘤治疗中的作用到抗菌作用以及促进伤口愈合的能力，我们展示了 HKUST-1 在应对生物医学关键挑战方面的多方面潜力。

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Unveiling the potential of HKUST-1: synthesis, activation, advantages and biomedical applications

Metal–organic frameworks (MOFs) have emerged as a unique class of nanostructured materials, resulting from the self-assembly of metal ions or clusters with organic ligands, offering a wide range of applications in fields such as drug delivery, gas catalysis, and electrochemical sensing. Among them, HKUST-1, a copper-based MOF, has gained substantial attention due to its remarkable three-dimensional porous structure. Comprising copper ions and benzene-1,3,5-tricarboxylic acid, HKUST-1 exhibits an extraordinary specific surface area and pronounced porosity, making it a promising candidate in biomedicine. Notably, the incorporation of copper ions endows HKUST-1 with noteworthy activities, including antitumor, antibacterial, and wound healing-promoting properties. In this comprehensive review, we delve into the various synthesis methods and activation pathways employed in the preparation of HKUST-1. We also explore the distinct advantages of HKUST-1 in terms of its structural properties and functionalities. Furthermore, we investigate the exciting and rapidly evolving biomedical applications of HKUST-1. From its role in tumor treatment to its antibacterial effects and its ability to promote wound healing, we showcase the multifaceted potential of HKUST-1 in addressing critical challenges in biomedicine.

更新日期：2024-02-27

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