Phylogeny-guided Characterization of Bacterial Hydrazine Biosynthesis Mediated by Cupin/methionyl tRNA Synthetase-like Enzymes,ChemBioChem

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Phylogeny-guided Characterization of Bacterial Hydrazine Biosynthesis Mediated by Cupin/methionyl tRNA Synthetase-like Enzymes
ChemBioChem ( IF 2.6 ) Pub Date : 2024-02-25 , DOI: 10.1002/cbic.202300838
Kenichi Matsuda ₁ , Yuto Nakahara ₁ , Atina Rizkiya Choirunnisa ₁ , Kuga Arima ₁ , Toshiyuki Wakimoto ₁

Affiliation

Flavin-dependent N-monooxygenases and cupin/methionyl-tRNA synthetase-like enzymes (hydrazine synthetases) are two key components of bacterial hydrazine biosynthetic pathways. Phylogenetic analysis of these two enzyme families provided a global perspective on the diversity of bacterial hydrazine biosynthesis. A phylogeny-guided enzyme-mining approach led to the identification of new bacterial hydrazines, including those based on 1,3-diaminopropane and putrescine.

中文翻译：

Cupin/甲硫氨酰 tRNA 合成酶样酶介导的细菌肼生物合成的系统发育指导表征

黄素依赖性N-单加氧酶和cupin/甲硫氨酰-tRNA合成酶样酶（肼合成酶）是细菌肼生物合成途径的两个关键组成部分。这两个酶家族的系统发育分析为细菌肼生物合成的多样性提供了全局视角。系统发育引导的酶挖掘方法导致了新细菌肼的鉴定，包括基于 1,3-二氨基丙烷和腐胺的细菌肼。

更新日期：2024-02-25

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