An ultrasound-assisted expedient protocol has been developed for the synthesis of imidazo[1,2-a]pyridines and imidazo[2,1-b]thiazoles by the C–H functionalization of ketones using a KI/tert-butyl hydroperoxide catalytic system. The reaction takes place in water, a green solvent, and does not require a metal catalyst; it also gives good yields of the products. The method offers numerous noteworthy characteristics, including mild reaction conditions, the absence of a base, broad functional-group compatibility, and excellent reaction yields. Moreover, it avoids the use of costly and air-sensitive chemicals, and can be conducted under ambient reaction conditions.

开发了一种超声辅助的简便方案，用于使用 KI/叔丁基过氧化氢催化系统通过酮的 C-H 官能化来合成咪唑并[1,2- a ]吡啶和咪唑并[2,1- b ]噻唑。反应在水这种绿色溶剂中进行，不需要金属催化剂；它还提供了良好的产品产量。该方法具有许多值得注意的特点，包括温和的反应条件、不存在碱、广泛的官能团兼容性和优异的反应产率。此外，它避免了使用昂贵且对空气敏感的化学品，并且可以在环境反应条件下进行。