METTL3 restrains autoimmunity in β-cells,Nature Cell Biology

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METTL3 restrains autoimmunity in β-cells
Nature Cell Biology ( IF 17.3 ) Pub Date : 2024-02-26 , DOI: 10.1038/s41556-024-01352-8
Balasubramanian Krishnamurthy _{1,

2} , Helen E Thomas _{1,

2}

Affiliation

Activation of innate immunity has been linked to the progression of type 1 diabetes. A study now shows that overexpression of METTL3, a writer protein of the m6A machinery that modifies mRNA, restrains interferon-stimulated genes when expressed in pancreatic β-cells, identifying it as a promising therapeutic target.

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