Nanozyme has been proven to be an attractive and promising candidate to alleviate the current pressing medical problems. However, the unknown clinical safety and limited function beyond the catalysis of the most reported nanozymes cannot promise an ideal therapeutic outcome in further clinical application. Herein, we find that ferric maltol (FM), a clinically approved iron supplement synthesized through a facile scalable method, exhibits excellent peroxidase-like activity than natural horseradish peroxidase-like (HRP) and commonly reported Fe-based nanozymes, and also shows high antibacterial performance for methicillin-resistant Staphylococcus aureus (MRSA) elimination (100%) and wound disinfection. In addition, with added effects inherited from contained maltol, FM can accelerate skin barrier recovery. Therefore, the exploration of FM as a safe and desired nanozyme provides a timely alternative to current antibiotic therapy against drug-resistant bacteria.

中文翻译：

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临床批准的麦芽酚铁：一种有效的纳米酶，具有高效催化消毒的附加作用

纳米酶已被证明是一种有吸引力且有前途的候选药物，可以缓解当前紧迫的医疗问题。然而，未知的临床安全性和大多数报道的纳米酶催化之外的有限功能不能保证在进一步的临床应用中获得理想的治疗结果。在此，我们发现麦芽酚铁（FM）是一种通过简单可扩展方法合成的临床批准的铁补充剂，与天然辣根过氧化物酶（HRP）和常见报道的铁基纳米酶相比，表现出优异的过氧化物酶样活性，并且还表现出较高的过氧化物酶活性。抗菌性能可消除耐甲氧西林金黄色葡萄球菌(MRSA)（100%）和伤口消毒。此外，FM 还继承了所含麦芽酚的附加作用，可以加速皮肤屏障的恢复。因此，探索 FM 作为一种安全且理想的纳米酶，为当前针对耐药细菌的抗生素治疗提供了及时的替代方案。