<br>Etrasimod：一种用于治疗溃疡性结肠炎的 1-磷酸鞘氨醇受体调节剂,Annals of Pharmacotherapy

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Etrasimod：一种用于治疗溃疡性结肠炎的 1-磷酸鞘氨醇受体调节剂
Annals of Pharmacotherapy ( IF 2.3 ) Pub Date : 2024-01-23 , DOI: 10.1177/10600280231225770
David Choi ₁ , Michelle Becker ₂ , Marina Ivanov ₃ , Shubha Bhat ₄

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目的：综述艾曲莫德治疗溃疡性结肠炎 (UC) 的药理学和临床概况。数据来源：从成立到 2023 年 11 月，使用关键词艾曲莫德、溃疡性结肠炎和 1-磷酸鞘氨醇受体调节剂进行 PubMed 搜索。信息还从已发表的摘要和说明书中获得。研究选择和数据提取：审查了 2 期和 3 期研究以及有关 etrasimod 药理学和临床概况的相关文献。数据合成：根据 ELEVATE，2 项 3 期研究，患者比例较高与安慰剂相比，中度至重度活动性 UC 在诱导和维持阶段获得了临床缓解。此外，与安慰剂相比，使用依曲莫德的患者达到临床反应、内镜改善-组织学缓解、无皮质类固醇缓解和内镜改善等次要终点的比例更高。常见的不良事件包括贫血和头痛。与现有药物相比，与患者护理和临床实践的相关性：Etrasimod 现在是第二种批准用于 UC 的口服 1-磷酸鞘氨醇调节剂，为患者提供了额外的治疗选择。这种治疗的有效率与其他 UC 药物选择一致。与其他1-磷酸鞘氨醇受体调节剂类似，在基线和治疗期间需要进行各种评估，以确保安全和适当使用。结论：Etrasimod是UC治疗装备中的另一种可能性，为患者提供更多的口服药物选择。在开始治疗之前，建议进行与安全性、药物相互作用和药物基因组学因素相关的多项评估。

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Etrasimod: A Sphingosine-1-Phosphate Receptor Modulator for the Treatment of Ulcerative Colitis

Objective:To review the pharmacologic and clinical profile of etrasimod in the treatment of ulcerative colitis (UC).Data sources:A PubMed search was conducted from inception to November 2023 using the keywords etrasimod, ulcerative colitis, and sphingosine-1-phosphate receptor modulator. Information was also obtained from published abstracts and package insert.Study selection and data extraction:Phase 2 and 3 studies plus relevant literature on etrasimod pharmacologic and clinical profile were reviewed.Data synthesis:Per ELEVATE, 2 phase 3 studies, a higher proportion of patients with moderately to severely active UC achieved clinical remission in the induction and maintenance phase with etrasimod compared with placebo. In addition, a higher proportion of patients achieved secondary endpoints of clinical response, endoscopic improvement-histologic remission, corticosteroid-free remission, and endoscopic improvement with etrasimod vs placebo. Common adverse events include anemia and headache.Relevance to patient care and clinical practice in comparison with existing drugs:Etrasimod is now the second orally administered sphingosine-1-phosphate modulator approved for UC, providing patients with additional treatment options. Efficacy rates of this treatment are in line with other UC medication options. Similar to other sphingosine-1-phosphate receptor modulators, various assessments are required at baseline and during treatment to ensure safe and appropriate use.Conclusion:Etrasimod is another possibility in the armamentarium of UC treatment, providing patients with more oral medication options. Prior to treatment initiation, several assessments relating to safety, drug interactions, and pharmacogenomics factors are advised.

更新日期：2024-01-23

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