Identification of ß-Glucocerebrosidase Activators for Glucosylceramide hydrolysis,ChemMedChem

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Identification of ß-Glucocerebrosidase Activators for Glucosylceramide hydrolysis
ChemMedChem ( IF 3.6 ) Pub Date : 2024-02-21 , DOI: 10.1002/cmdc.202300548
Monika-Sarah E D Schulze ₁ , Diana Scholz ₂ , Eric Jnoff ₂ , Adrian Hall ₂ , Jonathan Melin ₃ , Zara A Sands ₄ , Elizabeth Rodriguez ₁ , Veronique M Andre ₂

Affiliation

For the first time, we report novel compounds activating the hydrolysis of natural glucocerebrosidase (GCase) substrate glucosylceramide into ceramide and glucose. Compounds from two distinct chemotypes bind to two distinct sites on GCase: one (32) is located close to the substrate binding site while the other (31) is further away from the catalytic pocket. GlcCer: Glucosylceramide

中文翻译：

用于葡萄糖神经酰胺水解的 ß-葡萄糖脑苷脂酶激活剂的鉴定

我们首次报道了激活天然葡萄糖脑苷脂酶（GCase）底物葡萄糖神经酰胺水解成神经酰胺和葡萄糖的新型化合物。来自两种不同化学型的化合物结合到 GCase 上的两个不同位点：一个 ( 32 ) 靠近底物结合位点，而另一个 ( 31 ) 距离催化袋更远。 GlcCer：葡萄糖神经酰胺

更新日期：2024-02-21

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