<br>用于加速伤口修复的时空可控仿生皮肤,Small

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用于加速伤口修复的时空可控仿生皮肤
Small ( IF 13.0 ) Pub Date : 2024-02-22 , DOI: 10.1002/smll.202310556
Yuewei Chen ₁ , Weiying Lu ₂ , Yanyan Zhou ₂ , Zihe Hu ₂ , Haiyan Wu ₂ , Qing Gao ₁ , Jue Shi ₂ , Wenzhi Wu ₂ , Shang Lv ₁ , Ke Yao ₁ , Yong He ₁ , Zhijian Xie ₂

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皮肤损伤修复是一个动态过程，涉及一系列随时间和空间的相互作用。将人类生理过程与材料变化联系起来是一个重大挑战。为了配合伤口愈合过程，开发了一种时空可控的仿生皮肤，其中包括作为表皮的三维（3D）打印膜、作为真皮的含有细胞的水凝胶以及作为皮下组织的充满细胞因子的水凝胶。在仿生皮肤修复伤口的初始阶段，膜框架通过预张力帮助伤口闭合，同时细胞在水凝胶内增殖。接下来，随着框架随着时间的推移崩解，从水凝胶中释放的细胞沿着残留的膜迁移。在整个过程中，皮下水凝胶不断释放细胞因子，确保全面的营养。研究结果表明，在大鼠全层皮肤缺损模型中，仿生皮肤的伤口闭合率比空白组高八倍，胶原蛋白含量增加一倍，特别是在早期修复过程中。因此，有理由推断这种仿生皮肤具有加速伤口闭合和修复的巨大潜力。这种具有机械生物学效应和时空调节的仿生皮肤成为组织再生工程的一个有前途的选择。

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A Spatiotemporal Controllable Biomimetic Skin for Accelerating Wound Repair

Skin injury repair is a dynamic process involving a series of interactions over time and space. Linking human physiological processes with materials’ changes poses a significant challenge. To match the wound healing process, a spatiotemporal controllable biomimetic skin is developed, which comprises a three-dimensional (3D) printed membrane as the epidermis, a cell-containing hydrogel as the dermis, and a cytokine-laden hydrogel as the hypodermis. In the initial stage of the biomimetic skin repair wound, the membrane frame aids wound closure through pre-tension, while cells proliferate within the hydrogel. Next, as the frame disintegrates over time, cells released from the hydrogel migrate along the residual membrane. Throughout the process, continuous cytokines release from the hypodermis hydrogel ensures comprehensive nourishment. The findings reveal that in the rat full-thickness skin defect model, the biomimetic skin demonstrated a wound closure rate eight times higher than the blank group, and double the collagen content, particularly in the early repair process. Consequently, it is reasonable to infer that this biomimetic skin holds promising potential to accelerate wound closure and repair. This biomimetic skin with mechanobiological effects and spatiotemporal regulation emerges as a promising option for tissue regeneration engineering.

更新日期：2024-02-22

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