Dynamic Spinning Disc Reactor Technology to Enable In Situ Solid Product Formation in a Diazotization and Azo Coupling Sequence,Organic Process Research & Development

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Dynamic Spinning Disc Reactor Technology to Enable In Situ Solid Product Formation in a Diazotization and Azo Coupling Sequence
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2024-02-21 , DOI: 10.1021/acs.oprd.3c00448
Dominik Polterauer _{1,

2} , Kevin M. P. van Eeten ₃ , Wouter Stam ₃ , Christopher A. Hone _{1,

2} , C. Oliver Kappe _{1,

2}

Affiliation

Solid-forming reactions are notoriously challenging to process in standard flow processes. Even though the formation of a solid product within a reaction can facilitate simple purification, homogeneous reactions are often utilized to enable flow processing. We report the application of dynamic spinning disc reactor (SDR) technology as a strategy to handle in situ solid product formation while handling exothermic chemistry. The system is exemplified by using a diazotization and azo coupling reaction system. Advantages of the approach include the use of water as the sole reaction solvent, mild operating conditions (20 °C), and a simple isolation procedure by filtration and drying. We demonstrate that stable operation of the system is possible for 120 min, affording 55.9 g of Sudan II.

中文翻译：

动态旋转盘式反应器技术可在重氮化和偶氮偶联序列中原位形成固体产物

在标准流程中，固体形成反应的处理极具挑战性。尽管反应内固体产物的形成可以促进简单的纯化，但通常利用均相反应来实现流动处理。我们报告了动态旋转盘反应器（SDR）技术的应用，作为处理放热化学的同时处理原位固体产物形成的策略。该系统以重氮化和偶氮偶合反应系统为例。该方法的优点包括使用水作为唯一的反应溶剂、温和的操作条件（20°C）以及通过过滤和干燥进行的简单分离程序。我们证明系统可以稳定运行 120 分钟，提供 55.9 克苏丹 II。

更新日期：2024-02-21

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