The PWWP domain binds to both histone and DNA of a nucleosome in a bivalent way. PWWP domain-containing proteins are involved in different biological processes, and their aberrant expression is implicated in various human diseases. Here, we discuss the recent developments and challenges in targeting the PWWP domain for therapeutic intervention.

中文翻译：

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针对 PWWP 结构域的抑制剂开发进展

PWWP 结构域以二价方式与组蛋白和核小体 DNA 结合。含有PWWP结构域的蛋白质参与不同的生物过程，其异常表达与多种人类疾病有关。在这里，我们讨论针对 PWWP 域进行治疗干预的最新进展和挑战。