In recent years, isothiocyanates (ITCs), bioactive compounds primarily derived from vegetables and herbs, have gained significant attention within the biomedical field due to their versatile biological effects. This comprehensive review provides an in-depth exploration of the therapeutic potential and individual biological mechanisms of the three specific ITCs phenylethyl isothiocyanate (PEITC), allyl isothiocyanate (AITC), and benzyl isothiocyanate (BITC), as well as their collective impact within the formulation of ANGOCIN® (Angocin). Angocin comprises horseradish root (, 80 mg) and nasturtium ( 200 mg) and is authorized for treating inflammatory diseases affecting the respiratory and urinary tract. The antimicrobial efficacy of this substance has been confirmed both in vitro and in various clinical trials, with its primary effectiveness attributed to ITCs. PEITC, AITC, and BITC exhibit a wide array of health benefits, including potent anti-inflammatory, antioxidant, and antimicrobial properties, along with noteworthy anticancer potentials. Moreover, we highlight their ability to modulate critical biochemical pathways, such as the nuclear factor erythroid 2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), and signal transducer and activator of transcription (STAT) pathways, shedding light on their involvement in cellular apoptosis and their intricate role to guide immune responses.

中文翻译：

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医学中的异硫氰酸酯：苯乙基、烯丙基和苄基异硫氰酸酯的综合综述


近年来，异硫氰酸盐（ITC）这种主要来源于蔬菜和草药的生物活性化合物，由于其多种生物效应而在生物医学领域受到广泛关注。这篇全面的综述深入探讨了三种特定 ITC：异硫氰酸苯乙酯 (PEITC)、异硫氰酸烯丙酯 (AITC) 和异硫氰酸苄酯 (BITC) 的治疗潜力和各自的生物学机制，以及它们在配方中的集体影响ANGOCIN®（安戈辛）。 Angocin 含有辣根根（80 毫克）和金莲花（200 毫克），被授权用于治疗影响呼吸道和泌尿道的炎症性疾病。该物质的抗菌功效已在体外和各种临床试验中得到证实，其主要功效归功于 ITC。 PEITC、AITC 和 BITC 具有广泛的健康益处，包括有效的抗炎、抗氧化和抗菌特性，以及值得注意的抗癌潜力。此外，我们强调了它们调节关键生化途径的能力，例如核因子红细胞 2 相关因子 2 (Nrf2)/Kelch 样 ECH 相关蛋白 1 (Keap1)、激活的核因子 kappa 轻链增强子B 细胞 (NF-κB) 以及信号转导子和转录激活子 (STAT) 通路，揭示了它们参与细胞凋亡及其指导免疫反应的复杂作用。