Insulin-like growth factor 2 mRNA-binding proteins (IMPs, IGF2BPs) are RNA-binding proteins that regulate a variety of biological processes. In recent years, several studies have found that IGF2BPs play multiple roles in various biological processes, especially in cancer, and speculated on their mechanism of anticancer effect. In addition, targeting IGF2BPs or their downstream target gene has also received extensive attention as an effective treatment for different types of cancer. In this review, we summarized the recent progress on the role of IGF2BPs in cancers and their structural characteristics. We focused on describing the development of inhibitors targeting IGF2BPs and the prospects for further applications.

中文翻译：

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靶向胰岛素样生长因子 2 mRNA 结合蛋白 (IGF2BP) 治疗癌症


胰岛素样生长因子 2 mRNA 结合蛋白（IMP、IGF2BP）是调节多种生物过程的 RNA 结合蛋白。近年来，多项研究发现IGF2BPs在多种生物过程中，特别是在癌症中发挥多种作用，并推测其抗癌作用机制。此外，针对IGF2BPs或其下游靶基因作为针对不同类型癌症的有效治疗方法也受到广泛关注。在这篇综述中，我们总结了IGF2BP在癌症中的作用及其结构特征的最新进展。我们重点描述了针对 IGF2BP 的抑制剂的开发以及进一步应用的前景。