<br>镉暴露对杂色鲍肠道微生物群和抗生素抗性基因的影响,Chemosphere

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镉暴露对杂色鲍肠道微生物群和抗生素抗性基因的影响
Chemosphere ( IF 8.1 ) Pub Date : 2024-02-20 , DOI: 10.1016/j.chemosphere.2024.141507
Tuo Yao ₁ , Lingtong Ye ₂ , Sijie Wang ₃ , Jie Lu ₂ , Huan Li ₃ , Gang Yu ₂

Affiliation

土壤、水和工业生产中的重金属会影响细菌的抗生素耐药性。肠道微生物群的抗生素耐药性已得到广泛研究。研究了镉 (Cd) 对商业上重要的鲍鱼品种肠道微生物群和抗生素抗性基因 (ARG) 的影响。通过暴露于四种浓度的 Cd（0 μg·L（对照）、6.5 μg·L（低）、42.25 μg·L（中）和 274.63 μg·L（高））30 和 60 天，16 种 ARG（、、、、、、、、、、、、、、、、、、、、）、1213属、27门微生物组。 ARG 可耐受氨基糖苷类、β-内酰胺酶、大环内酯-林可酰胺-链阳菌素 B、多药、氟苯尼考、大环内酯、磺胺类、四环素类和万古霉素。镉暴露显着改变、、、和的丰度。约 5% (61) 的属级微生物受到镉暴露的显着影响。 60 天 42.25 μg L Cd 处理中微生物群 α 和 β 多样性与其他处理显着不同。此外，还检测到26种病原体，其中两种病原体（和）受镉暴露影响显着。接触 Cd 60 天后，随着 Cd 浓度的增加，病原体和 ARG 之间的显着相关性也增加。镉暴露可能会导致肠道微生物群紊乱，并增加 ARG 转移至病原体的可能性，从而增加潜在的生态和经济风险。

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Effects of cadmium exposure on gut microbiota and antibiotic resistance genes in Haliotis diversicolor abalone

Heavy metals in soil, water, and industrial production can affect the antibiotic resistance of bacteria. Antibiotic resistance in gut microbiota has been extensively researched. The effects of cadmium (Cd) was investigated on the gut microbiota and antibiotic resistance genes (ARGs) of , a commercially important abalone species. By exposing to four concentrations of Cd (0 μg L (control), 6.5 μg L (low), 42.25 μg L (medium), and 274.63 μg L (high)) for 30 and 60 days, 16 types of ARG (, , , , , , , , , , , , , , , ), and 1213 genus and 27 phylum microbiomes were detected. ARGs can be resistant to aminoglycoside, beta-lactamase, macrolide-lincosamide-streptogramin B, multidrug, florfenicol, macrolide, sulfonamides, tetracyclines, and vancomycin. Cadmium exposure significantly alters the abundance of , , , , and . About 5% (61) of genus-level microorganisms were significantly affected by Cd exposure. Microbiota alpha and beta diversities in the 60-day 42.25 μg L Cd treatment differed significantly from those in other treatments. In addition, 26 pathogens were detected, and two pathogens ( and ) were significantly affected by Cd exposure. Significant correlations between pathogens and ARGs increased with increased Cd concentration after 60 days of Cd exposure. Cadmium exposure may cause gut microbiota disturbance in and increase the likelihood of ARG transfer to pathogens, increasing potential ecological and economic risks.

更新日期：2024-02-20

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