Polyetheretherketone (PEEK) is increasingly recognized as a promising biomaterial for orthopedic implants due to its mechanical properties that are very similar to those of human bones. However, its inherent bioinertness still poses a challenge to effective osseointegration, and surface modification of PEEK implants often faces limitations such as multi-step complexity. In this study, we innovatively developed a dopamine-triggered one-step polymerization of 3-[(3-acrylamidopropyl)dimethylammonio] propanoate (PCBAA), which in situ induced biomineralization and constructed a functional PEEK biointerfaces, directly and effectively enhancing osseointegration and antibacterial effects. The successful immobilization of PCBAA on the surface of PEEK significantly enhanced osteogenic differentiation of bone mesenchymal stem cells, as evidenced by the significant improvement in alkaline phosphatase activity and mineral deposition. Moreover, the functional biointerfaces exhibited substantialantibacterial efficacy in vitro. Micro-computed tomography (micro-CT) and histological evaluation of rat tibia implantation showed that compared to uncoated screws, the PCBAA-functionalized PEEK screws significantly enhanced new bone formation and possessed superior pull-out strength. The findings of this study suggest that the one-step polymerization of PCBAA coatings on PEEK substrates is facile and can efficiently overcome the limitations of current surface modification. The resultant PCBAA-coated PEEK biointerfaces have shown great promise in promoting osseointegration and mitigating postoperative infections for clinical outcomes of PEEK-based orthopedic implants.

中文翻译：

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两性离子聚合物功能化聚醚醚酮生物界面通过原位诱导生物矿化增强骨整合和抗菌作用

聚醚醚酮 (PEEK) 由于其机械性能与人体骨骼非常相似，越来越被认为是一种有前途的骨科植入物生物材料。然而，其固有的生物惰性仍然对有效的骨整合提出了挑战，而且PEEK种植体的表面修饰往往面临多步骤复杂性等限制。在本研究中，我们创新性地开发了一种多巴胺触发的3-[(3-丙烯酰氨基丙基)二甲基铵]丙酸酯(PCBAA)的一步聚合，其原位诱导生物矿化并构建功能性PEEK生物界面，直接有效地增强骨整合和抗菌作用影响。 PCBAA在PEEK表面的成功固定显着增强了骨间充质干细胞的成骨分化，碱性磷酸酶活性和矿物质沉积的显着改善证明了这一点。此外，功能性生物界面在体外表现出显着的抗菌功效。大鼠胫骨植入的显微计算机断层扫描 (micro-CT) 和组织学评估表明，与未涂层螺钉相比，PCBAA 功能化 PEEK 螺钉显着增强了新骨形成，并具有优异的拔出强度。这项研究的结果表明，在 PEEK 基材上进行 PCBAA 涂层的一步聚合是很容易的，并且可以有效地克服当前表面改性的局限性。由此产生的 PCBAA 涂层 PEEK 生物界面在促进骨整合和减轻术后感染方面显示出巨大的前景，从而实现基于 PEEK 的骨科植入物的临床结果。