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The thin line between monooxygenases and peroxygenases. P450s, UPOs, MMOs, and LPMOs: A brick to bridge fields of expertise
Biotechnology Advances ( IF 12.1 ) Pub Date : 2024-02-08 , DOI: 10.1016/j.biotechadv.2024.108321
Davide Decembrino , David Cannella

Many scientific fields, although driven by similar purposes and dealing with similar technologies, often appear so isolated and far from each other that even the vocabularies to describe the very same phenomenon might differ. Concerning the vast field of biocatalysis, a special role is played by those redox enzymes that employ oxygen-based chemistry to unlock transformations otherwise possible only with metal-based catalysts. As such, greener chemical synthesis methods and environmentally-driven biotechnological approaches were enabled over the last decades by the use of several enzymes and ultimately resulted in the first industrial applications. Among what can be called today the environmental biorefinery sector, biomass transformation, greenhouse gas reduction, bio-gas/fuels production, bioremediation, as well as bulk or fine chemicals and even pharmaceuticals manufacturing are all examples of fields in which successful prototypes have been demonstrated employing redox enzymes.

中文翻译:

单加氧酶和过加氧酶之间的细线。 P450、UPO、MMO 和 LPMO:连接专业领域的砖块

许多科学领域虽然受到相似的目的驱动并处理相似的技术,但往往显得彼此孤立且相距甚远,甚至描述同一现象的词汇也可能有所不同。在广阔的生物催化领域中,那些氧化还原酶发挥着特殊的作用,它们利用氧基化学来解锁只有金属基催化剂才能实现的转化。因此,在过去的几十年中,通过使用多种酶实现了更绿色的化学合成方法和环境驱动的生物技术方法,并最终实现了首次工业应用。在当今所谓的环境生物炼制领域中,生物质转化、温室气体减排、沼气/燃料生产、生物修复以及散装或精细化学品甚至药品制造都是已展示成功原型的领域的例子使用氧化还原酶。
更新日期:2024-02-08
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