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Utility of 2-Chloro-N-arylacetamide and 1,1′-(Piperazine-1,4-diyl)bis(2-chloroethanone) as Versatile Precursors for Novel Mono- and Bis[thienopyridines]
ACS Omega ( IF 3.7 ) Pub Date : 2024-02-21 , DOI: 10.1021/acsomega.3c06653 Mostafa E Salem 1, 2 , Abbas H Abdullah 2 , Magdi E A Zaki 1 , Ismail A Abdelhamid 2 , Ahmed H M Elwahy 2
ACS Omega ( IF 3.7 ) Pub Date : 2024-02-21 , DOI: 10.1021/acsomega.3c06653 Mostafa E Salem 1, 2 , Abbas H Abdullah 2 , Magdi E A Zaki 1 , Ismail A Abdelhamid 2 , Ahmed H M Elwahy 2
Affiliation
A series of novel thieno[2,3-b]pyridines linked to N-aryl carboxamides or (carbonylphenoxy)-N-(aryl)acetamides, as well as bis(thieno[2,3-b]pyridines) linked to piperazine core via methanone or carbonylphenoxyethanone units, were synthesized by treating the appropriate chloroacetyl- or bis-bromoacetyl derivatives with 2-mercaptonicotinonitrile derivatives in ethanolic sodium ethoxide at reflux. The spectral data were used to determine the compositions of novel compounds.
中文翻译:
2-氯-N-芳基乙酰胺和1,1'-(哌嗪-1,4-二基)双(2-氯乙酮)作为新型单-和双[噻吩并吡啶]的多功能前体的用途
一系列新型噻吩并[2,3- b ]吡啶与N-芳基甲酰胺或(羰基苯氧基) -N- (芳基)乙酰胺连接,以及双(噻吩并[2,3- b ]吡啶)与哌嗪核心连接通过甲酮或羰基苯氧基乙酮单元,通过在乙醇乙醇钠中在回流下用2-巯基烟腈衍生物处理适当的氯乙酰基或双溴乙酰基衍生物来合成。光谱数据用于确定新化合物的组成。
更新日期:2024-02-21
中文翻译:
2-氯-N-芳基乙酰胺和1,1'-(哌嗪-1,4-二基)双(2-氯乙酮)作为新型单-和双[噻吩并吡啶]的多功能前体的用途
一系列新型噻吩并[2,3- b ]吡啶与N-芳基甲酰胺或(羰基苯氧基) -N- (芳基)乙酰胺连接,以及双(噻吩并[2,3- b ]吡啶)与哌嗪核心连接通过甲酮或羰基苯氧基乙酮单元,通过在乙醇乙醇钠中在回流下用2-巯基烟腈衍生物处理适当的氯乙酰基或双溴乙酰基衍生物来合成。光谱数据用于确定新化合物的组成。