药物应用微胶囊：综述,ACS Applied Bio Materials

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药物应用微胶囊：综述
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2024-02-06 , DOI: 10.1021/acsabm.3c00776
Cuie Yan ₁ , Sang-Ryoung Kim ₁

Affiliation

为了提高活性药物成分（API）的生物利用度、稳定性、控释和靶向递送，以及掩盖其苦味，提高其功效，并最大限度地减少其副作用，各种微胶囊化（包括纳米胶囊化），粒径<100 nm）技术已广泛应用于制药行业。常用的微胶囊技术有乳液、凝聚、挤出、喷雾干燥、冷冻干燥、分子包合、微泡和微海绵、流化床包衣、超临界流体胶囊、静电纺丝/喷雾和聚合。在这篇综述中，API根据其分子复杂性进行分类：小API（低分子量化合物，如阿司匹林、布洛芬和大麻二酚）、中API（中等分子量化合物，如胰岛素、肽和核酸）和活体API。微生物（例如益生菌、细菌和噬菌体）。本文概述了这些微胶囊技术，包括它们的工艺、基质以及它们在 API 微胶囊中的最新应用。此外，还全面分析了这些常见的微囊化技术在提高API药物治疗功效方面的优缺点。目的是总结 API 微囊化的最新进展，以提高其生物利用度、控制释放、靶向递送、掩盖其苦味和稳定性，从而提高其功效并最大限度地减少其副作用。最后，强调了微胶囊在药物应用中的未来前景。

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Microencapsulation for Pharmaceutical Applications: A Review

In order to improve bioavailability, stability, control release, and target delivery of active pharmaceutical ingredients (APIs), as well as to mask their bitter taste, to increase their efficacy, and to minimize their side effects, a variety of microencapsulation (including nanoencapsulation, particle size <100 nm) technologies have been widely used in the pharmaceutical industry. Commonly used microencapsulation technologies are emulsion, coacervation, extrusion, spray drying, freeze-drying, molecular inclusion, microbubbles and microsponge, fluidized bed coating, supercritical fluid encapsulation, electro spinning/spray, and polymerization. In this review, APIs are categorized by their molecular complexity: small APIs (compounds with low molecular weight, like Aspirin, Ibuprofen, and Cannabidiol), medium APIs (compounds with medium molecular weight like insulin, peptides, and nucleic acids), and living microorganisms (such as probiotics, bacteria, and bacteriophages). This article provides an overview of these microencapsulation technologies including their processes, matrix, and their recent applications in microencapsulation of APIs. Furthermore, the advantages and disadvantages of these common microencapsulation technologies in terms of improving the efficacy of APIs for pharmaceutical treatments are comprehensively analyzed. The objective is to summarize the most recent progresses on microencapsulation of APIs for enhancing their bioavailability, control release, target delivery, masking their bitter taste and stability, and thus increasing their efficacy and minimizing their side effects. At the end, future perspectives on microencapsulation for pharmaceutical applications are highlighted.

更新日期：2024-02-06

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