This review provides an overview of the latest applications of sulfonated molecules in biomaterials. Sulfonation, a chemical modification process introducing sulfonic acid groups, enhances biomaterial properties. This review explores the effect of sulfonation and recent innovations in biomaterial applications. It covers hydrogels, scaffolds, and nanoparticles, emphasizing sulfonation’s unique advantages. The impact on cellular responses, including adhesion, proliferation, and differentiation, is discussed. This review also addresses sulfonated biomaterials’ role in regenerative medicine, drug delivery, and tissue engineering challenges. It also provides a small overview of the sources and features of marine-derived sulfonated molecules, emphasizing their potential roles in advancing scientific research. As a novel aspect, an unconventional complex, “traditional Chinese medicine” and its sulfonation method have come to the forefront after a thousand years of history. This article concludes with a reflection on current research and future avenues, highlighting sulfonation’s transformative potential in biomedicine.

中文翻译：

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磺化分子及其在生物材料领域的最新应用：综述

本综述概述了磺化分子在生物材料中的最新应用。磺化是一种引入磺酸基团的化学改性过程，可增强生物材料的性能。本综述探讨了磺化的影响以及生物材料应用中的最新创新。它涵盖了水凝胶、支架和纳米颗粒，强调了磺化的独特优势。讨论了对细胞反应的影响，包括粘附、增殖和分化。本综述还讨论了磺化生物材料在再生医学、药物输送和组织工程挑战中的作用。它还对海洋磺化分子的来源和特征进行了简要概述，强调了它们在推进科学研究方面的潜在作用。作为一种新颖的、非常规的复合体，“中药”及其磺化方法在经历了一千多年的历史之后，已经走到了风口浪尖。本文最后反思了当前的研究和未来的发展方向，强调了磺化在生物医学领域的变革潜力。