<br>失调的 JNK 信号通路在人类疾病发病机制中的作用及其潜在治疗策略：综合综述,Biomolecules

当前位置： X-MOL 学术 › Biomolecules › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

失调的 JNK 信号通路在人类疾病发病机制中的作用及其潜在治疗策略：综合综述
Biomolecules ( IF 4.8 ) Pub Date : 2024-02-19 , DOI: 10.3390/biom14020243
Huaying Yan ₁ , Lanfang He ₁ , De Lv ₂ , Jun Yang ₃ , Zhu Yuan ₃

Affiliation

JNK 以 c-Jun N 末端激酶命名，因为它负责磷酸化 c-Jun。作为丝裂原激活蛋白激酶（MAPK）家族的一员，JNK也被称为应激激活激酶（SAPK），因为它可以被生长因子、紫外线照射和病毒感染等细胞外应激激活。从功能上讲，JNK 调节各种细胞行为，如细胞分化、增殖、存活和代谢重编程。 JNK 信号传导失调会导致多种类型的人类疾病。尽管之前的几篇出版物已经总结了 JNK 通路在单一疾病中的作用，但缺乏对其在多种人类疾病中的作用的全面综述。在这篇综述中，我们首先介绍 JNK 通路的里程碑式发现、结构、组织表达和激活机制。接下来我们就来到本次工作的重点：全面总结失调的JNK通路在多种疾病中的作用。除此之外，我们还讨论了当前针对 JNK 通路进行治疗干预的策略，并总结了 JNK 抑制剂的应用以及目前面临的几个挑战。我们期望这篇综述能够更全面地揭示JNK通路在人类疾病发病机制中的关键作用，并希望它也为改善疾病状况提供重要线索。

"点击查看英文标题和摘要"

The Role of the Dysregulated JNK Signaling Pathway in the Pathogenesis of Human Diseases and Its Potential Therapeutic Strategies: A Comprehensive Review

JNK is named after c-Jun N-terminal kinase, as it is responsible for phosphorylating c-Jun. As a member of the mitogen-activated protein kinase (MAPK) family, JNK is also known as stress-activated kinase (SAPK) because it can be activated by extracellular stresses including growth factor, UV irradiation, and virus infection. Functionally, JNK regulates various cell behaviors such as cell differentiation, proliferation, survival, and metabolic reprogramming. Dysregulated JNK signaling contributes to several types of human diseases. Although the role of the JNK pathway in a single disease has been summarized in several previous publications, a comprehensive review of its role in multiple kinds of human diseases is missing. In this review, we begin by introducing the landmark discoveries, structures, tissue expression, and activation mechanisms of the JNK pathway. Next, we come to the focus of this work: a comprehensive summary of the role of the deregulated JNK pathway in multiple kinds of diseases. Beyond that, we also discuss the current strategies for targeting the JNK pathway for therapeutic intervention and summarize the application of JNK inhibitors as well as several challenges now faced. We expect that this review can provide a more comprehensive insight into the critical role of the JNK pathway in the pathogenesis of human diseases and hope that it also provides important clues for ameliorating disease conditions.

更新日期：2024-02-19

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文