ERK5 kinase activity is dispensable for cellular immune response and proliferation [Cell Biology],Proceedings of the National Academy of Sciences of the United States of America

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ERK5 kinase activity is dispensable for cellular immune response and proliferation [Cell Biology]
Proceedings of the National Academy of Sciences of the United States of America ( IF 9.4 ) Pub Date : 2016-10-18 09:32:52 , DOI: 10.1073/pnas.1609019113
Emme C. K. Lin ₁ , Christopher M. Amantea ₁ , Tyzoon K. Nomanbhoy ₁ , Helge Weissig ₁ , Junichi Ishiyama ₂ , Yi Hu ₁ , Shyama Sidique ₁ , Bei Li ₁ , John W. Kozarich ₁ , Jonathan S. Rosenblum ₁

Affiliation

Unlike other members of the MAPK family, ERK5 contains a large C-terminal domain with transcriptional activation capability in addition to an N-terminal canonical kinase domain. Genetic deletion of ERK5 is embryonic lethal, and tissue-restricted deletions have profound effects on erythroid development, cardiac function, and neurogenesis. In addition, depletion of ERK5...

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