Continuous 24-hour intraocular pressure monitoring in normal Chinese adults using a novel contact lens sensor system,British Journal of Ophthalmology

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Continuous 24-hour intraocular pressure monitoring in normal Chinese adults using a novel contact lens sensor system
British Journal of Ophthalmology ( IF 3.7 ) Pub Date : 2024-11-01 , DOI: 10.1136/bjo-2023-323361
Yuning Zhang ₁ , Yifan Wei ₁ , Ching Hymn Christopher Lee ₂ , Ping Wai Or ₂ , Isuru Kaweendra Karunaratne ₂ , Mingjie Deng ₁ , Wenxin Yang ₁ , Iok Tong Chong ₂ , Yangfan Yang ₁ , Zidong Chen ₁ , Yanmei Fan ₁ , David C C Lam ₃ , Minbin Yu ₄

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Aims To investigate the physiological nyctohemeral intraocular pressure (IOP) rhythms of normal Chinese adults using a novel contact lens sensor system (CLS) that can output IOP in millimetres of mercury (mm Hg) continuously. Methods Fifty-nine eyes of 59 normal Chinese adults completed 24-hour IOP monitoring using the novel CLS. A descriptive analysis was conducted on the 24-hour IOP mean, peak and acrophase, trough and bathyphase, fluctuation, and mean amplitude of intraocular pressure excursion (MAPE). The continuous data were analysed at several periods (diurnal period, 08:00–20:00 hours; nocturnal period, 22:00–06:00 hours; sleep time, 0:00–06:00 hours), and compared between right and left eyes, males and females, and different age ranges (<30, and ≥30), respectively. Results Normal adults had a lower peak, higher trough, smaller fluctuation and smaller MAPE (p<0.05 for all comparisons) but non-significantly different mean (p=0.695) in the nocturnal period or sleep time compared with the diurnal period. The 24-hour IOP peak and trough showed the frequency of occurrence ranging from 1.69% to 15.25% at an interval of 2 hours. No IOP parameter showed significant difference between right and left eyes (p>0.1 for all comparisons). The male group had larger 24-hour and diurnal IOP fluctuation and MAPE (p<0.05 for all comparisons). Subjects aged 30 or over had higher 24-hour and diurnal mean, higher peak, and larger MAPE (p<0.05 for all comparisons). Conclusion Continuous 24-hour IOP output from the CLS in normal Chinese was stable with a comparable mean level between day and night, as well as scattered acrophase and bathyphase. The 24-hour IOP mean increased with age, and IOP variations were positively correlated to age and male sex. Data are available on reasonable request.

更新日期：2024-10-22

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