当前位置:
X-MOL 学术
›
bioRxiv. Evol. Biol.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Fusion, fission, and scrambling of the bilaterian genome in Bryozoa
bioRxiv - Evolutionary Biology Pub Date : 2024-09-11 , DOI: 10.1101/2024.02.15.580425
Thomas D. Lewin , Isabel Jiah-Yih Liao , Mu-En Chen , John D. D. Bishop , Peter W. H. Holland , Yi-Jyun Luo
bioRxiv - Evolutionary Biology Pub Date : 2024-09-11 , DOI: 10.1101/2024.02.15.580425
Thomas D. Lewin , Isabel Jiah-Yih Liao , Mu-En Chen , John D. D. Bishop , Peter W. H. Holland , Yi-Jyun Luo
Groups of orthologous genes are commonly found together on the same chromosome over vast evolutionary distances. This extensive physical gene linkage, known as macrosynteny, is seen between bilaterian phyla as divergent as Chordata, Echinodermata, Mollusca, and Nemertea. Here, we report a unique pattern of genome evolution in Bryozoa, an understudied phylum of colonial invertebrates. Using comparative genomics, we reconstruct the chromosomal evolutionary history of five bryozoans. Multiple ancient chromosome fusions followed by gene mixing led to the near-complete loss of bilaterian linkage groups in the ancestor of extant bryozoans. A second wave of rearrangements, including chromosome fission, then occurred independently in two bryozoan classes, further scrambling bryozoan genomes. We also discover at least five derived chromosomal fusion events shared between bryozoans and brachiopods, supporting the traditional but highly debated Lophophorata hypothesis. Finally, we show that chromosome fusion and fission processes led to the partitioning of genes from bryozoan Hox clusters onto multiple chromosomes. Our findings demonstrate that the canonical bilaterian genome structure has been lost across all studied representatives of an entire phylum; reveal that linkage group fission can occur very frequently in specific lineages; and provide a powerful source of phylogenetic information.
中文翻译:
苔藓虫中两侧对称动物基因组的融合、裂变和置乱
直系同源基因组通常在较长的进化距离内一起出现在同一条染色体上。这种广泛的物理基因连锁,被称为宏同线性,存在于脊索动物门、棘皮动物门、软体动物门和纽虫门等不同的两侧对称动物门之间。在这里,我们报告了苔藓虫门的基因组进化的独特模式,苔藓虫门是一个尚未被研究的群体无脊椎动物门。利用比较基因组学,我们重建了五种苔藓虫的染色体进化史。多个古代染色体融合以及随后的基因混合导致现存苔藓虫祖先的两侧对称动物连锁群几乎完全丧失。随后,包括染色体裂变在内的第二波重排在两个苔藓虫纲中独立发生,进一步扰乱了苔藓虫基因组。我们还发现苔藓动物和腕足动物之间至少有五个衍生的染色体融合事件,支持了传统但备受争议的 Lophophorata 假说。最后,我们发现染色体融合和裂变过程导致苔藓虫 Hox 簇中的基因分配到多个染色体上。我们的研究结果表明,在整个门的所有研究代表中,典型的两侧对称动物基因组结构已经丢失。揭示连锁群裂变在特定谱系中可能非常频繁地发生;并提供系统发育信息的强大来源。
更新日期:2024-09-11
中文翻译:
![](https://scdn.x-mol.com/jcss/images/paperTranslation.png)
苔藓虫中两侧对称动物基因组的融合、裂变和置乱
直系同源基因组通常在较长的进化距离内一起出现在同一条染色体上。这种广泛的物理基因连锁,被称为宏同线性,存在于脊索动物门、棘皮动物门、软体动物门和纽虫门等不同的两侧对称动物门之间。在这里,我们报告了苔藓虫门的基因组进化的独特模式,苔藓虫门是一个尚未被研究的群体无脊椎动物门。利用比较基因组学,我们重建了五种苔藓虫的染色体进化史。多个古代染色体融合以及随后的基因混合导致现存苔藓虫祖先的两侧对称动物连锁群几乎完全丧失。随后,包括染色体裂变在内的第二波重排在两个苔藓虫纲中独立发生,进一步扰乱了苔藓虫基因组。我们还发现苔藓动物和腕足动物之间至少有五个衍生的染色体融合事件,支持了传统但备受争议的 Lophophorata 假说。最后,我们发现染色体融合和裂变过程导致苔藓虫 Hox 簇中的基因分配到多个染色体上。我们的研究结果表明,在整个门的所有研究代表中,典型的两侧对称动物基因组结构已经丢失。揭示连锁群裂变在特定谱系中可能非常频繁地发生;并提供系统发育信息的强大来源。