We read Arnold et al ’s article1 with interest and wanted to extend this work to Africa. A high incidence of oesophageal squamous cell carcinoma (OSCC) has been reported in African countries from Kenya to South Africa2 where early-onset (age <45 years) OSCC accounts for 30% of cases in the region. As such, we examined the cumulative lifetime and age-specific incidences of OSCC in Africa. We identified patients with OSCC in three major African cancer registries, using the 2013–2017 Cancer Incidence in Five Continents Volume XII (CI5-XII) database and calculated the age-specific, cumulative lifetime and cumulative early-onset incidence of early-onset OSCC, all of which will allow us to account for the underlying age structure of the population. We identified 1022 patients diagnosed with OSCC between 2013 and 2017, of which 47.2% (n=482) were females and 12.3% (n=126) were <45 years old consistent with early-onset OSCC (figure 1). Region-level proportions of early-onset OSCC cases varied from 7.6% (26/340) in Eastern Cape, South Africa, to 15.6% (60/384) in Nairobi, Kenya. The cumulative lifetime incidence and cumulative incidence3 of early-onset OSCC were 1508 and 33 cases per 100 000 person-year, respectively, and early-onset OSCC only accounted for 2.2% of cumulative lifetime incidence …

中文翻译：

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重新评估非洲早发性 OSCC：最小累积发病率的发现


我们饶有兴趣地阅读了 Arnold 等人的文章1，并希望将这项工作扩展到非洲。据报道，从肯尼亚到南非的非洲国家/地区，食管鳞状细胞癌 （OSCC） 的发病率很高2，其中早发性（年龄 <45 岁）OSCC 占该地区病例的 30%。因此，我们检查了非洲 OSCC 的累积终生和年龄特异性发病率。我们使用 2013-2017 年五大洲癌症发病率第 XII 卷 （CI5-XII） 数据库在非洲三个主要癌症登记处确定了 OSCC 患者，并计算了早发性 OSCC 的年龄特异性、累积寿命和累积早发性发病率，所有这些都将使我们能够解释人群的基本年龄结构。我们确定了 2013 年至 2017年间诊断为 OSCC 的 1022 例患者，其中 47.2% （n=482） 为女性，12.3% （n=126） 为 <45 岁，与早发性 OSCC 一致（图 1）。区域层面的早发性 OSCC 病例比例从南非东开普省的 7.6% （26/340） 到肯尼亚内罗毕的 15.6% （60/384） 不等。早发性 OSCC 的累积终生发病率和累积发病率3分别为 1508 例/100 000 人和 33 例/100 000 人年，而早发型 OSCC 仅占累积终生发病率的 2.2%。